antianginal/hypoxia

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Local specificity in responses of canine coronary vessels to oxygen deficiency and antianginal drugs.

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Influence of oxygen deficiency and vasodilating drugs on coronary arterial tonus was investigated. In the fibrillating heart, hypoxia initially decreased total coronary resistance, later increased it, and exerted little effect on large coronary arteries. Dilation of helically cut specimens of the

Anti-anginal drugs and the vasodilator response to myocardial hypoxia.

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Protective activity of some anti-anginal drugs on asphyxic anoxia of the brain; a contribution to their laboratory evaluation.

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Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells.

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BACKGROUND Claudin-5, claudin-9, and claudin-11 are expressed in endothelial cells to constitute tight junctions, and their deficiency may lead to hyperpermeability, which is the initiating process and pathological basis of cardiovascular disease. Although tongxinluo (TXL) has satisfactory

Ranolazine attenuates the enhanced reverse Na⁺-Ca²⁺ exchange current via inhibiting hypoxia-increased late sodium current in ventricular myocytes.

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Ranolazine (RAN), a novel antianginal agent, inhibits the increased late sodium current (INa.L) under many pathological conditions. In this study, the whole-cell patch-clamp technique was used to explore the effects of RAN on INa.L and reverse Na(+)/Ca(2+) exchange current (INCX) in rabbit

Antianginal effects of the new calcium antagonist benidipine hydrochloride in anesthetized rats and spontaneously hypertensive rats. Electrocardiographic study.

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Antianginal effects of (+/-)-(R*)-2,6-dimethyl-4-(m-nitrophenyl)- 1,4-dihydropyridine-3,5-dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049) in various experimental angina-pectoris models (anesthetized rats, spontaneously hypertensive

Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation.

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This study was undertaken to evaluate the direct cardioprotective effect of trimetazidine (TMZ), an anti-anginal drug devoid of haemodynamic action, on isolated myocytes. Cultured rat ventricular myocytes were treated with the drug 16 h and 1 h before the experiments. The drug-treated cells and

Effects of a new antianginal agent, nicorandil, on normoxic and anoxic contractions in isolated miniature pig coronary arteries exposed to 5-hydroxytryptamine and norepinephrine: comparison with nitroglycerin and diltiazem.

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Nicorandil, nitroglycerin and diltiazem effects on normoxic and anoxic contractile responses to 5-hydroxytryptamine (5-HT) and norepinephrine (NE) were compared in isolated miniature pig coronary artery strips. Anoxia augmented contractile responses of the strips to 5-HT and NE. Nicorandil and

Examination of the direct effects of antianginal agents on the hypoxic canine myocardium.

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The myocardial protective effect of nicorandil, N-(2-hydroxyethyl) nicotinamide nitrate ester, against hypoxia was examined in comparison with that of nitroglycerin in 22 open chest dogs. The regional ventricular myocardium was perfused for 5 min with a hypoxic solution in 8 dogs (Group 1), with a

Trimetazidine: in vitro influence on heart mitochondrial function.

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The mechanism of action of the antianginal trimetazidine (TMZ) remains largely unknown. In cultured rat ventricular myocytes in physiologic conditions, TMZ (5 x 10(-4) M) reduced the plateau potential level, the upstroke velocity, and the spontaneous action potential rate. When the cardiomyocytes

Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study.

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OBJECTIVE Renal ischemia reperfusion (IR) injury (IRI) is an important mechanism of acute renal failure (ARF) and a crucial factor of tissue damage during vascular surgery. IR may lead to tissue destruction and influence the early and long-term outcome of organs. The anti-anginal medication

Cardiac metabolism in ischemic heart disease.

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Myocardial ischemia is the metabolic consequence of an inadequate blood supply to the myocardium. How does the myocardium survive a severe insult? Ischemia, perhaps acting through hypoxia, is able to induce a series of cellular signals that lead to protective genetic reprogramming. Metabolic

Comparative effects of bepridil and verapamil on isolated coronary and systemic vascular and cardiac muscle.

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The relaxant effects of the antianginal agent bepridil, a drug with calcium antagonistic actions, and verapamil on isolated pig coronary (C) and rabbit aortic (A) smooth muscle were compared. Both drugs competitively antagonised calcium in Tris buffered but not in bicarbonate buffered medium. Both

Riluzole: Anti-invasive effects on rat prostate cancer cells under normoxic and hypoxic conditions.

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Anti-invasive effects of riluzole and ranolazine, a neuro-protectant and an antianginal drug, respectively, on Mat-LyLu rat prostate cancer (PCa) cells were tested in vitro (i) at non-toxic doses and (ii) under both normoxic and hypoxic conditions, the latter common to growing tumours. Tetrodotoxin

8-Bromo cyclic GMP inhibits NADH and lactate accumulation in hypoxic rat atria.

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The effects of 8-bromo-cGMP on tissue lactate and NADH levels were studied under conditions of high oxygen saturation (95-100%) and hypoxia (50%) in spontaneously beating rat atria. The induction of hypoxia caused a rapid decline in contractility with a simultaneous increase in tissue lactate and

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