antianginal/neoplasms

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Fendiline, an anti-anginal drug, increases intracellular Ca2+ in PC3 human prostate cancer cells.

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BACKGROUND The effects of the anti-anginal drug fendiline on intracellular Ca2+ concentrations ([Ca2+]i) in human PC3 prostate cancer cells were examined. METHODS [Ca2+]i was measured using the fluorescent dye fura-2. RESULTS Fendiline (0.5-100 microM) increased [Ca2+]i in a concentration-dependent

Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells.

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Ranolazine, a piperazine derivative, is currently approved for the treatment of chronic angina. However, its ionic mechanisms in other types of cells remain unclear, although it is thought to be a selective blocker of late Na(+) current. This study was conducted to evaluate the possible effects of

Alterations in macrophage free radical and tumor necrosis factor production by a potassium channel activator.

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The potassium channel activator nicorandil, under evaluation for antianginal management, has been shown to decrease neutrophil respiratory burst. Since our laboratory has demonstrated that reactive oxygen species (ROS) increase tumor necrosis factor (TNF) production, we hypothesized that nicorandil

Riluzole: Anti-invasive effects on rat prostate cancer cells under normoxic and hypoxic conditions.

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Anti-invasive effects of riluzole and ranolazine, a neuro-protectant and an antianginal drug, respectively, on Mat-LyLu rat prostate cancer (PCa) cells were tested in vitro (i) at non-toxic doses and (ii) under both normoxic and hypoxic conditions, the latter common to growing tumours. Tetrodotoxin

Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate.

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BACKGROUND

Voltage-gated Na⁺ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug,

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

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BACKGROUND Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine

Surgery in patients with coronary artery disease--silent ischaemia during transurethral resection of tumors of prostate or bladder.

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BACKGROUND Asymptomatic episodes of myocardial ischemia in clinically stable patients seem to occur frequently and may hint at a worse prognosis. OBJECTIVE This study was undertaken to determine whether surgical patients with coronary artery disease (CAD) have a higher risk of cardiac ischemia

Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor.

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BACKGROUND Platinum-based chemotherapeutic regimens, including BEP (bleomycin, etoposide, cisplatin) represent the standard of care, first line therapy in non-epithelial ovarian tumours. Cardiovascular toxicity is a rare adverse effect of bleomycin. METHODS A 41-year-old woman with ovarian granulosa

Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice.

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Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD,

Atrial fibrillation observed in a patient with esophageal cancer treated with fluorouracil.

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Fluorouracil (5-FU), a commonly used anticancer agent, has potent cardiotoxicity that is mediated by vascular endothelial injury and vasospasm. Here, we report a patient demonstrating atrial fibrillation (AF), which was most likely induced by vasospasm mediated by 5-FU. A 69-year-old man presented

Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

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Sir James Black developed β-blockers, one of the most useful groups of drugs in use today. Not only are they being used for their original purpose to treat angina and cardiac arrhythmias, but they are also effective therapeutics for hypertension, cardiac failure, glaucoma, migraine and anxiety.

Pharmacology of Ranolazine versus Common Cardiovascular Drugs in Patients with Early Diastolic Dysfunction Induced by Anthracyclines or Nonanthracycline Chemotherapeutics: A Phase 2b Minitrial.

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We have reported that anthracyclines and nonanthracycline chemotherapeutics caused diastolic dysfunction in cancer patients without cardiovascular risk factors. Diastolic dysfunction occurred as early as 1 week after the last chemotherapy cycle and manifested as impaired myocardial relaxation at

Testosterone and other anabolic steroids as cardiovascular drugs.

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There has been much interest in the effect of sex hormones on cardiovascular risk factors and as a therapeutic modality in both men and women. In this article, testosterone is considered as a possible therapy for cardiovascular disease. It has been shown that the level of serum testosterone

Postoperative myocardial ischemia: epidural versus intravenous patient-controlled analgesia. A pilot project.

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OBJECTIVE Continuous postoperative epidural analgesia with bupivacaine (BUP) and morphine (MS) may be associated with a decreased incidence of postoperative myocardial ischemia (ISCH) and infarction (MI). This study evaluated the incidence of ISCH and MI in patients with two or more risk factors for

Gemcitabine-induced acute coronary syndrome: a case report.

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OBJECTIVE To report a case of metastatic leiomyosarcoma, in which a patient developed chest pain accompanied by acute left bundle-branch block (LBBB) after gemcitabine infusion. METHODS A 59-year-old woman admitted with bilateral pulmonary nodules had classic risk factors for coronary heart disease

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