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ArticlesClinical trialsPatents
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Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

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BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenases, Ed., J. Rokach, Elsevier, N.Y., 1989. Inhibitors of the

Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

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BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenase, Ed., J. Rokach, Elsevier, N.Y., 1989. Inhibitors of the

(Quinolin-2-ylmethoxy)indole/cyclodextrin complex

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BACKGROUND OF THE INVENTION EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-

(Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

(hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes

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CROSS REFERENCE The compounds of Formula I' are described in U.S. Ser. No. 650,825 filed Feb. 5, 1991, which is now U.S. Pat. No. 5,204,344, and incorporated herein by reference. BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds

Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility

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BACKGROUND OF THE INVENTION EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-

Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases

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BACKGROUND OF THE INVENTION EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-

(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes

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BACKGROUND OF THE INVENTION European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing

3-hetero-substituted-N-benzyl-indoles and medical methods of use therefor

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BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their roles in various disease states and conditions have been described. For example, see EP 140,684 (May 8, 1985), which is incorporated herein by reference. Several classes of compounds exhibit ability to

Quinoline ether alkanoic acids

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BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their roles in various disease states and conditions have been described. For example, see U.S. Pat. No. 4,683,325 (Jul. 28, 1987), which is incorporated herein by reference. Several classes of compounds exhibit
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