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anticoagulant/neoplasms
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Composition and method for sulfated non-anticoagulant low molecular weight heparins in cancer and tumor metastasis
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TECHNICAL FIELD
The present invention relates to compositions and associated methods for suppression of primary tumor growth and metastasis by use of sulfated, super-sulfated non-anticoagulant low and ultra-low molecular weight heparins, and their nanoformulations.
BACKGROUND
The Glycosaminoglycans
Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
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BACKGROUND OF THE INVENTION
The present invention relates to glycosaminoglycan derivatives useful in the inhibition of endoglycosidase activity and of tumor invasiveness or metastatic spread.
A class of biological substances called the proteoglycans form the ground substance in the extracellular
Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients
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FIELD OF THE INVENTION
This invention relates to the prevention and treatment of tumor growth, metastasis, and cancer associated thromboembolic disorders, and more particularly to such treatment by the administration of a lyophilized formulation of an antiplatelet such as the platelet GPIIb/IIIa
Compositions and methods for stabilizing circulating tumor cells
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FIELD OF THE INVENTION
The teachings herein relate to devices and methods for stabilizing and preserving circulating tumor cells without damaging the tumor cell integrity for improved protection and regulation of circulating tumor cells during collection, storage, and shipment.
BACKGROUND OF THE
Compositions and methods for stabilizing circulating tumor cells
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FIELD OF THE INVENTION
The teachings herein relate to devices and methods for stabilizing and preserving circulating tumor cells without damaging the tumor cell integrity for improved protection and regulation of circulating tumor cells during collection, storage, and shipment.
BACKGROUND OF THE
Anticoagulant analogues of the tissue factor extrinsic pathway inhibitor (EPI) with reduced affinity for heparin
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FIELD OF THE INVENTION
The present invention relates to new protein analogues of the Extrinsic Pathway Inhibitor (EPI; also known as Tissue Factor Pathway Inhibitor, TFPI, or Lipoprotein-Associated Pathway Inhibitor, LACI). The invention also features a method of making the analogues and therapeutic
Subcutaneously administrable composition containing anti-IL-6 antibody
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BACKGROUND OF THE INVENTION
Field of the Invention
This invention is an extension of Applicants' prior invention disclosed in the above-referenced patent applications relating to novel anti-IL-6 antibodies, novel therapies and therapeutic protocols utilizing anti-IL-6 antibodies, and pharmaceutical
Method of treating allergic asthma with antibodies to IL-6
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The sequence listing in the file named "56256o2006.txt" having a size of 332,224 bytes that was created Sep. 26, 2017 is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Field of the Invention
This invention is an extension of Applicants' prior invention disclosed in the
Therapeutic uses of bactericidal/permeability increasing protein (BPI) protein products
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BACKGROUND OF THE INVENTION
The present invention relates to therapeutic uses of bactericidal/permeability increasing (BPI) protein products for the treatment of conditions related to gram-negative bacterial infection and the conditions not directly associated with gram-negative bacterial infection,
Therapeutic uses of bactericidal/permeability increasing protein products
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BACKGROUND OF THE INVETION
The present invention relates to therapeutic uses of bactericidal/permeability increasing (BPI) protein products for the treatment of conditions related to gram-negative bacterial infection and the conditions not directly associated with gram-negative bacterial infection,
Therapeutic uses of bactericidal/permeability increasing protein products
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BACKGROUND OF THE INVENTION
The present invention relates to therapeutic uses of bactericidal/permeability increasing (BPI) protein products for the treatment of conditions related to gram-negative bacterial infection and the conditions not directly associated with gram-negative bacterial infection,
Therapeutic uses of bactericidal/permeability increasing protein products
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BACKGROUND OF THE INVENTION
The present invention relates to therapeutic uses of bactericidal/permeability increasing (BPI) protein products for the treatment of conditions not directly associated with gram negative bacterial infection including neutralization of the anti-coagulant properties of
Cell growth method and pharmaceutical preparation for tissue repair and regeneration
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TECHNICAL FIELD
The present invention relates to: a method for growing, rapidly and massively ex vivo, cells collected from a living subject; cells grown by the method; a pharmaceutical preparation for biological tissue repair and regeneration comprising the cells; and a method for producing the
Cell growth method and pharmaceutical preparation for tissue repair and regeneration
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CROSS-REFERENCE TO RELATED APPLICATION
This application is the U.S. National Stage of PCT International Application PCT/J P2008/002503, filed Sep. 10, 2008, and claims the benefit of foreign priority under 35 U.S.C. .sctn.119 based on JP Appln No. 2007-235436, filed Sep. 11, 2007, JP Appln. No.
Rationally designed polysaccharide lyases derived from chondroitinase B
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FIELD OF THE INVENTION
The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and
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