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anticoagulant/stroke
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PKC activators and anticoagulant in regimen for treating stroke
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The present disclosure relates generally to administration of an anticoagulant, e.g., recombinant tissue plasminogen activator (rTPA), and a protein kinase C (PKC) activator followed by administering at least one PKC activator for a duration of treatment to treat a subject following ischemic stroke.
PKC activators and anticoagulant in regimen for treating stroke
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The present disclosure relates generally to administration of an anticoagulant, e.g., recombinant tissue plasminogen activator (rTPA), and a protein kinase C (PKC) activator followed by administering at least one PKC activator for a duration of treatment to treat a subject following ischemic stroke.
Oral anticoagulant/platelet inhibitor low dose formulation
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BACKGROUND OF THE INVENTION
1. Field of Invention
This invention relates to combination products comprising low doses of oral anticoagulants, such as warfarin, and low doses of inhibitors of platelet function (e.g., aggregation, adhesion) such as non-steroidal antiinflammatory agents, and preferably
Anticoagulant compounds, pharmaceutical compositions on their basis to treat thrombotic conditions, and plasma-substituting solution to correct hypercoagulation defects of hemodilution
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FIELD OF THE INVENTION
This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications in diseases such as myocardial
Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity
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FIELD OF THE INVENTION
The present invention relates to variants (mutants) of recombinant protein C and activated protein C, an enzyme that normally has anti-thrombotic, anti-inflammatory, and anti-apoptotic activities. The recombinant activated protein C mutants of the invention have markedly
Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity
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FIELD OF THE INVENTION
The present invention relates to variants (mutants) of recombinant protein C and activated protein C, an enzyme that normally has anti-thrombotic, anti-inflammatory, and anti-apoptotic activities. The recombinant activated protein C mutants of the invention have markedly
Treatment of stroke using placental stem cells
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1. INTRODUCTION
The present invention relates to methods of exsanguinating and perfusing a placenta following expulsion from the uterus, e.g., after birth. The present invention relates to methods of treating and culturing an isolated placenta for the propagation of embryonic-like stem cells
Protein fusion constructs possessing thrombolytic and anticoagulant properties
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SEQUENCE LISTING SUBMISSION VIA EFS-WEB
A computer readable text file, entitled "102082-5002_SequenceListing.txt," created on or about 23 Sep. 2013, with a file size of about 160 kb contains the sequence listing for this application and is hereby incorporated by reference in its entirety.
FIELD OF
Method and compositions for inhibiting thrombin-induced coagulation
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FIELD OF THE INVENTION
The present invention relates in general to SdrG, a fibrinogen-binding bacterial adhesin, and in particular to the use of SdrG or its binding region as an anti-coagulation agent by virtue of its ability to inhibit thrombin-induced fibrin clot formation by interfering with the
Methods for treating atrial fibrillation
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BACKGROUND
Atrial fibrillation (AF) is a common cardiac disorder characterized transient to permanent replacement of the normal, coordinated electrical impulses generated by the sinoatrial (SA) node by disorganized electrical impulses originating in the atria and pulmonary veins. An irregular
Antagonists of IL-6 to prevent or treat thrombosis
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is an extension of Applicants' prior invention disclosed in the above-referenced patent applications relating to novel anti-IL-6 antibodies and novel therapies and therapeutic protocols using anti-IL-6 antibodies, preferably those
Therapy for treatment or prevention of conditions associated with bleeding or hypocoagulation
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The sequence listing file named "41112o1001.txt," having a size of 34,530 bytes and created May 4, 2016, is hereby incorporated by reference in its entirety.
FIELD OF THE INVENTION
The present application generally relates to methods and compositions for use in such methods, for preventing or
Barrier device for ostium of left atrial appendage
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a membrane or plug structure applied to the ostium of an atrial appendage for preventing blood flow and physical connection between an atrium of the heart and the associated atrial appendage or appendages to isolate an
Barrier device for ostium of left atrial appendage
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a membrane or plug structure applied to the ostium of an atrial appendage for preventing blood flow and physical connection between an atrium of the heart and the associated atrial appendage or appendages to isolate an
Barrier device for ostium of left atrial appendage
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a membrane or plug structure applied to the ostium of an atrial appendage for preventing blood flow and physical connection between an atrium of the heart and the associated atrial appendage or appendages to isolate an
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