It has been found in experiments on unanesthetized rabbits that arecoline administered to the lateral ventricle of the brain produced an action which was opposite to that of leukocytic pyrogen. It inhibited the activity of individual neurons of the posterior hypothalamus and decreased the body
Experiments on rats were made to study the effect on the body temperature of the rat of intracerebroventricular injection of venoms of Indian cobra, North American rattle snake, and Central Asian shchitomordnik. It was established that the rise of rectal temperature by 1.5-2.0 degrees C after 90 min
It was shown in experiments on unanesthetized rats with prostaglandin E2 (PGE2) hyperthermia, not preventable by aspirin that intraventricular (into the lateral ventricle) injections of arecoline, noradrenaline, 5-hydroxytryptamine (5-HT), histamine, and calcium ions and intraperitoneal eserine
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