asthma/proline

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Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.

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BACKGROUND Small proline rich protein 2B (SPRR2B) is a skin and lung epithelial protein associated with allergic inflammation in mice that has not been evaluated in human atopic diseases. OBJECTIVE To determine whether single-nucleotide polymorphisms (SNPs) in SPRR2B are associated with childhood

CD26 and Asthma: a Comprehensive Review.

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Asthma is a heterogeneous and chronic inflammatory family of disorders of the airways with increasing prevalence that results in recurrent and reversible bronchial obstruction and expiratory airflow limitation. These diseases arise from the interaction between environmental and genetic factors,

Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract.

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Using antibodies to basic and acidic proline-rich proteins (PRP) of salivary origin, we detected PRP immunoreactivity in serous cells of human nasal, laryngeal, and tracheobronchial glands by an immunoperoxidase technique. Immunoreactive PRP, detected by immunoblotting from SDS gels, were also found

Association of a chromosome 1q21 locus in close proximity to a late cornified envelope-like proline-rich 1 (LELP1) gene with total serum IgE levels.

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The chromosomal region 1q21 has been linked to atopic dermatitis in previous studies. Seven polymorphic repeats were identified in a 0.5 Mb region of chromosome 1q21 encompassing a small proline-rich protein (SPRR) gene cluster, a few S100 gene family members, loricin, and several uncharacterized

A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma.

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The human chromosomal 5q31-33 region has been implicated as a susceptibility locus for several immune-mediated diseases including asthma in several populations. Recently, the extraneuronal GABAergic system has been implicated as a new link to airway obstruction in asthma. In addition, the SLC6A7

[Arginine metabolism in bronchial asthma].

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Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Airway inflammation is associated with an enhanced expression of inducible nitric oxide synthase. This increases nitric oxide production and results in higher levels of NO* gas in exhaled

Alterations in plasma amino acid levels in children with asthma: a preliminary investigation.

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Concentrations of plasma amino acids and cortisol were measured in 27 children with status asthmaticus, moderate, or mild asthma and in 7 controls without lung disease. Individuals with conditions potentially altering amino acid levels were excluded. Measurements were made at 8 A.M. and 4 P.M. on

p38 mitogen-activated protein kinase pathways in asthma and COPD.

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The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been

A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma.

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BACKGROUND Microarray data from mouse studies have identified a number of genes to be differentially expressed in allergen-sensitized mice lungs. OBJECTIVE Taking leads from these datasets, we attempted to identify novel genes associated with atopic asthma in humans. METHODS We performed

Bronchospasmolytic and Adenosine Binding Activity of 8- (Proline / Pyrazole)-Substituted Xanthine Derivatives

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Background: ABSTRACT: Background: 8-Phenyltheophylline derivatives exhibit prophylactic effects at a specific dose but do not produce the cardiovascular or emetic side effects associated with xanthines, thereby exhibiting unique

The therapeutic potential of drugs targeting the arginase pathway in asthma.

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Arginine metabolism by arginases may be of importance in health and disease, either by competing with nitric oxide synthases for the common substrate or by the production of L-ornithine. L-ornithine serves as a precursor for L-proline and polyamines, which may be involved in tissue remodelling by

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma.

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BACKGROUND Childhood asthma is classified into allergic asthma (AA) and nonallergic asthma (NA), yet both are treated identically, with only partial success. OBJECTIVE We sought to identify novel immune phenotypes for childhood AA and NA. METHODS The Clinical Asthma Research Association cohort study

Arginine homeostasis in allergic asthma.

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Allergic asthma is a chronic disease characterized by early and late asthmatic reactions, airway hyperresponsiveness, airway inflammation and airway remodelling. Changes in l-arginine homeostasis may contribute to all these features of asthma by decreased nitric oxide (NO) production and increased

Metabolomics in asthma: where do we stand?

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Metabolomics has been used to uncover the metabolic signatures of asthma, both for biomarker identification and pathophysiologic mechanisms research. We aimed to review recent advances in this field, published since 2016, and discuss these findings implications to future research and application

Arginase and arginine dysregulation in asthma.

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In recent years, evidence has accumulated indicating that the enzyme arginase, which converts L-arginine into L-ornithine and urea, plays a key role in the pathogenesis of pulmonary disorders such as asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide (NO)

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