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Ivermectin and Nitazoxanide Combination Therapy for COVID-19

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Selected Drugs Ivermectin has anti-parasitic effect along with anti-viral activity against a broad range of viruses in vitro. Ivermectin was identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

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Vagus nerve stimulation (VNS) has an established history of reducing airway distress. VNS has at least two mechanisms of action that may profoundly affect respiratory function in patients with respiratory distress due to CoViD-19. First, vagus nerve stimulation modulates bronchoconstriction, acute

Coordinated HEalthcare for Complex Kids

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The University of Illinois Health and Health Sciences System (UI Health) developed an integrated care management quality improvement model designed to provide comprehensive care coordination for Medicaid insured minority children and young adults with chronic health conditions living in Chicago.

Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level

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The Gaming for Medical Education Research (G4MER) Program

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The "G4MER" Program aims to perform a series of randomised control trials on different groups at Sydney Children's Hospital: 1. Study 1A (Formerly titled "Serious Games in Medical Education - a Randomised Control Trial") is already underway and involves Phase 3 medical students at UNSW having 8

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

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MATERIALS AND METHODS After approval of the institutional Ethics committee board, written informed consent will be taken from all the eligible and willing patients. A. Study design: Randomized double blind active controlled parallel group noninferiority clinical trial. B. Randomization: A variable

COMPLliancE and qualiTy of lifE in Asthma

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Dry powder devices, available since 1970, have been developed to make inhalation simpler than pMDIs and relieve the need for co-ordination of spraying and inhalation, which is particularly important for patient groups such as the elderly and children. In addition, dry powder devices do not contain

A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy

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Optimizing Vitamin D status during pregnancy it thought to have maternal, fetal, and neonatal benefit. Studies suggest that Vitamin D acts well beyond its most commonly thought of role in establishing calcium homeostasis and maintaining maternal and neonatal skeletal integrity. Vitamin D has also

Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation

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Any patient weighing >2 kg between the ages of > 37 weeks corrected gestational age and <18 years who is intubated and mechanically ventilated will be eligible for the study. We seek to group patients into 3 potential cohorts: i. Normal Lungs (maximum 30 patients): Mechanically ventilated patients

Vitamin D, Iodine, and Lead Levels in Haitian Infants and Children.

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BACKGROUND: 1. Vitamin D Deficiency Vitamin D deficiency is common in the United States and worldwide, including in infants and children 1,2. Moderate to severe deficiency in children can manifest as rickets, a skeletal disease which results from a failure of mineralization of developing bones and

Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children.

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Treatment of Low Metabolic Rate Following Bariatric Surgery

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Research Objectives: The primary objective is to apply an effective medical weight loss treatment to post bariatric surgery patients to enhance their weight loss through stimulation of thermogenesis and lipolysis and retention of lean body mass. This treatment using ephedrine with phosphodiesterase

Safety of MenACWY-CRM Vaccination in Adolescents

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This is an observational study, vaccines administration and data that is collected is only as part of routine clinical care. Vaccinated subjects are not actively recruited. Events of interest: Seizure, Aseptic meningitis, Bell's Palsy, Multiple Sclerosis, Guillain-Barre Syndrome, Acute disseminated

Target Temperature Management After Cardiac Arrest

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Detailed statistical analysis plan for the Target Temperature Management after Out-of-hospital Cardiac Arrest trial 1. Introduction The Target temperature management after out-of-hospital cardiac arrest, a randomised, parallel-group, assessor-blinded clinical trial (the TTM-trial) is the largest

Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax

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Background: Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males (1, 2). The estimated recurrence rate is 23-50% after the first episode (3). Optimal treatment of patients presenting with a first episode of primary spontaneous pneumothorax remains unknown. In the recently

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