astrocytoma/hypoxia

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Inhibition of SENP1 for the Suppression of OS Growth and Metastasis

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Background: Osteosarcoma (OS) is the most common type of primary malignant bone tumor in children and adolescents. The overall survival rate is dramatically reduced by the development of metastases, often pulmonary. Solid malignant tumors, such as OS, often develop a hypoxic microenvironment, which

The Etiology and Progression of Brain Tumors

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Aims of the study: 1. To collect adequate brain cancer tissue material for high throughput morphological, protein, RNA and DNA analyses. 2. To combine tissue-related results of these analyses with clinical data to examine the potential of the new biomarkers to assess diagnosis, prognosis and

Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma

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PRIMARY OBJECTIVES: I. To evaluate the safety and toxicity profile of intravenous bevacizumab (avastin) administered in combination with oral AZD2171 (cediranib maleate) for patients with advanced malignancies. II. To determine the pharmacokinetic profile of oral AZD2171 in combination with

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