Patient with ADHD diagnosis criterion. The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach

Patient with symptom of hyperactivity and/or attention deficiency but without ADHD diagnosis criterion.
The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach.

Adhd

Biological samples (blood and urine) for a multimodal metabolomic approach

Metabolomic approach

University Hospital TOURS

Identification of Biomarkers of Attention Deficit Disorder With or Without Hyperactivity (ADHD) by a Metabolomic Approach in Children

Detection of metabolites (phenylalanine or catécholamines) in the blood of patients with ADHD at levels significantly different from baseline levels in the general population and rates found in patients with attention deficit and / or hyperactivity disorders but that multidisciplinary assessment excludes the diagnosis of ADHD.

Detection of metabolites (phenylalanine or catécholamines) in the urine of patients with ADHD at levels significantly different from baseline levels in the general population and rates found in patients with attention deficit and / or hyperactivity disorders but that multidisciplinary assessment excludes the diagnosis of ADHD.

University Hospital, Tours

Cognitive Change

Cathodal transcranial direct current stimulation over the dorsolateral prefrontal cortex

Cathodal Transcranial direct current stimulation

L-Tyrosine

Transcranial direct current stimulation (sham)

Cellulose (placebo)

Psychology laboratories

Dopamine Dorsolateral Prefrontal Cortex Behavioural Flexibility

Dopaminergic Contribution to Behavioural Flexibility as Modulated by Transcranial Direct-current Stimulation of the Dorsolateral Prefrontal Cortex

Sheffield Hallam University

Saracatinib will be given orally at a dose of 125 milligrams once daily for 9 months. Saracatinib is provided as a pink tablet.

Pulmonary Lymphangioleiomyomatosis

Subjects will receive enough tablets for 90 days +/- 14 days at each visit. Subject will have visits every 90 days for drug accountability as well as safety and efficacy testing to include pulmonary function testing, laboratory testing to include liver and kidney profile, urine pregnancy testing at each visit, vital signs, physical examination - any medically significant changes from baseline visit will be recorded, all adverse events will be monitored until resolution.

autism/tyrosine

Identification of Biomarkers of Attention Deficit Disorder With or Without Hyperactivity (ADHD) by a Metabolomic Approach in Children

Dopamine Dorsolateral Prefrontal Cortex Behavioural Flexibility

Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis

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