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6 results
Mechanisms of protective effects of berbamine on ischemia/reperfusion injury in isolated rat heart.
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Isolated perfused rat heart model was used to observe the protective effects of berbamine on myocardial ischemia/reperfusion injury. The hearts were significantly injured by 40 min global ischemia followed by 20 min reperfusion. Berbamine could significantly improve heart function, prevent
[Mechanism of the protective effects of berbamine on ischemia-reperfusion injury in isolated rat heart].
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Isolated perfused rat heart model was used to observe the protective effects of berbamine on myocardial ischemia/reperfusion injury. The hearts were remarkably injured by 40 min global ischemia followed by 20 min reperfusion. Berbamine could significantly improve heart function, prevent ventricular
Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy.
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Pretreatment of berbamine protects the heart from ischemia/reperfusion (I/R) injury. However it is unknown whether it has cardioprotection when given at the onset of reperfusion (postconditioning (PoC)), a protocol with more clinical impact. Autophagy is upregulated in I/R myocardium and exacerbates
Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca(2+) homeostasis and preventing calpain activation.
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BACKGROUND
Berbamine, a natural compound from Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown.
RESULTS
Berbamine pretreatment from 10 to 100nmol/L concentration-dependently improved post-ischemic myocardial
[Progress of cardiovascular pharmacologic study on berbamine].
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Berbamine (molecular formular C37H40N2O6) is a bi-benzle-isoquinolyl alkaloid extracted from Berberis poiretil Schneid (genus of Berberis, family of Beridaceae), a kind of Chinese plants. In aspect of cardiovascular pharmacology, berbamine shows actions of anti-arrhythmia, anti-myocardial ischemia,
Effects of berbamine on hemodynamics and myocardial reperfusion injury in isolated working rabbit hearts.
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The isolated working rabbit hearts perfused with Tyrode's buffer solution persisted working in good condition at least up to 70 min. Berbamine (Ber) 3 mumol.L-1 significantly changed the hemodynamic parameters and reduced cardiac functions. The effects of Ber appeared in a dose-dependent manner.
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