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beta lapachone/neoplasms
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14 results
Pharmaceutical compositions of .beta.-lapachone and .beta.-lapachone analogs with improved tumor targeting potential
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FIELD OF THE INVENTION
The present invention relates to improved compositions and methods for delivering therapeutic agents bearing carbonyl or quinone functionalities and improved methods for treating cancer. One embodiment of the invention relates to improved .beta.-lapachone compositions and
Substituted .beta.-lapachones for treating cancer
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BACKGROUND
Mitochondria play important roles in tumor cell physiology and survival by providing energy and metabolites for growth and proliferation. As part of their oncogenic status, cancer cells frequently produce increased levels of mitochondrial-generated reactive oxygen species (ROS). However,
Synthesis and use of .beta.-lapachone analogs
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BACKGROUND OF THE INVENTION
X-irradiation and chemotherapy are used to eliminate neoplastic cells. It has been found that a chemical post-treatment with .beta.-lapachone analogs after X-irradiation greatly enhanced the lethality of the radiation and/or chemotherapy and destroy more neoplastic cells.
Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth
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FIELD OF THE INVENTION
This invention is directed to novel o-quinone and o-naphthoquinone derivatives which are structurally related to naturally-occurring lapachones and dunniones. The present invention is also drawn to a novel synthetic method to produce tricyclic derivatives, including lapachone
Method of treating hematologic tumors and cancers
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BACKGROUND OF THE INVENTION
Multiple myeloma ("MM") represents a malignant proliferation of plasma cells derived from a single clone. The terms multiple myeloma and myeloma are used interchangeably to refer to the same condition. The myeloma tumor, its products, and the host response to it result in
PH-sensitive compositions for delivery of beta lapachone and methods of use
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BACKGROUND
.beta.-Lapachone (.beta.-lap) is a natural product isolated from the lapacho tree in South America. Beta lapachone is a potent cytotoxic anticancer agent with antitumor activity against a variety of human cancer cells, including drug resistant cell lines. Recent studies uncovering its
Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
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FIELD OF THE INVENTION
The present invention is directed to pharmaceutical compositions and formulations, as well as methods of administering these pharmaceutical compositions and formulations, which comprise .beta.-lapachone (Beta-lapachone), or a derivative or analog thereof, complexed or combined
Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
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FIELD OF THE INVENTION
The present invention is directed to pharmaceutical compositions and formulations, as well as methods of administering these pharmaceutical compositions and formulations, which comprise .beta.-lapachone (Beta-lapachone), or a derivative or analog thereof, complexed or combined
Synthesis of .beta.-lapachone and its intermediates
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FIELD OF THE INVENTION
The present invention is directed to a process for the synthesis of .beta.-lapachone (Beta-lapachone) and lapachol, the .beta.-lapachone (Beta-lapachone) intermediate, which are important agents in cancer chemotherapy.
BACKGROUND OF THE INVENTION
Over 1.22 million new cancer
Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
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FIELD OF THE INVENTION
This invention is directed to novel o-quinone and o-naphthoquinone derivatives which are structurally related to naturally-occurring lapachones and dunniones. The present invention is also drawn to a novel synthetic method to produce tricyclic derivatives, including lapachone
Lapachone compounds and methods of use thereof
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BACKGROUND OF THE INVENTION
.beta.-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), a quinone, is derived from lapachol (a naphthoquinone) which can be isolated from the lapacho tree (Tabebuia avellanedae), a member of the catalpa family (Bignoniaceae). Lapachol and
Lapachone compounds and methods of use thereof
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BACKGROUND OF THE INVENTION
.beta.-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), a quinone, is derived from lapachol (a naphthoquinone) which can be isolated from the lapacho tree (Tabebuia avellanedae), a member of the catalpa family (Bignoniaceae). Lapachol and
Treatment of human prostate disease
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BACKGROUND OF THE INVENTION
The present invention is directed to a method of treating an individual suffering from benign prostate hyperplasmia and prostate cancer.
The prostate gland produces several components of semen in blood and several regulatory peptides. The prostate gland comprises stroma
Methods of protecting against radiation injury
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BACKGROUND OF THE INVENTION
Exposure to ionizing radiation (such as X-rays, gamma rays, and alpha- or beta-radiation) can cause damage to cells. This damage can result in cell death (e.g., through apoptosis), or can cause genetic changes in the cell, resulting in unchecked cell proliferation and
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