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4 results
Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.
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Sterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by
Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties.
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Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This
Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice.
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Obesity is a critical risk factor for hepatocellular carcinoma (HCC). However, it remains unknown whether inhibition of de novo lipid biosynthesis can suppress HCC. In this study, we blocked the sterol regulatory element-binding protein (SREBP) pathway, one of the key determinants of lipid
Torenia concolor Lindley var. formosana Yamazaki extracts improve inflammatory response and lipid accumulation via PPARs activation.
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Background/Introduction: At present, human diet is replete with sugar and fat. Abnormal metabolism and hyperglycemia or hyperlipidemia in the body induces the development of an overactive and continuous inflammatory response, resulting in obesity and metabolic syndromes, including hypertension,
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