biotin/inflammation

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Co-administration of an agent linked to an internalization peptide with an anti-inflammatory

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REFERENCE TO A SEQUENCE LISTING SUBMITTED IN A COMPUTER READABLE FORMAT The sequence listing written in the file 483620_SEQLST.txt is 18,070 bytes, and was created on Aug. 23, 2016 and is hereby incorporated by reference. BACKGROUND OF THE INVENTION Many drugs are required to be taken up by cells or

Co-administration of an agent linked to an internalization peptide with an anti-inflammatory

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REFERENCE TO A SEQUENCE LISTING SUBMITTED IN A COMPUTER READABLE FORMAT The sequence listing written in the file 413219_SEQLST.TXT is 18,027 bytes, and was created on Jun. 11, 2012 and is hereby incorporated by reference. BACKGROUND OF THE INVENTION Many drugs are required to be taken up by cells or

Co-administration of an agent linked to an internalization peptide with an anti-inflammatory

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BACKGROUND OF THE INVENTION Many drugs are required to be taken up by cells or pass through cells and/or be taken up by cellular organelles to reach their intended therapeutic target. Many larger molecules and some small ones by themselves have limited capacity to pass through cellular membranes.

Biotin esters of rapamycin

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BACKGROUND OF THE INVENTION This invention relates to biotin derivatives of rapamycin and a method for using them for inducing immunosuppression; in the treatment of transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections,

Enterobactin conjugates and uses thereof

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BACKGROUND OF THE INVENTION Siderophores are low-molecular-weight high-affinity Fe(III) chelators that are biosynthesized and exported by bacteria, fungi, and plants during periods of nutrient limitation for acquiring this essential metal ion from the extracellular milieu..sup.1,2 Both

Withanolides, probes and binding targets and methods of use thereof

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FIELD OF THE INVENTION The present invention relates to compounds for targeting human or animal disease states characterized by aberrant expression of the intermediate filament type III proteins, such as vimentin, methods and compounds for detecting intermediate filament type III proteins, such as

Method for producing oligosaccharide, and novel oligosaccharide and pharmaceutical composition containing the same

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BACKGOUND OF THE INVENTION The present invention relates to a method for producing an oligosaccharide. The present invention also relates to a novel oligosaccharide and a pharmaceutical composition containing it. Keratan sulfate is a glycosaminoglycan comprising, as a basic structure, N-acetyl

Platinum complexes for targeted drug delivery

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BACKGROUND OF THE INVENTION Platinum complexes, the prototype being cisplatin (Cis-Pt), have been widely used as active anticancer agents (Ardizzoni et al., 1999; Nitiss, 2002) in a variety of human tumors, including testicular, ovarian, bladder carcinoma, head and neck, and non-small cell lung

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