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Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis

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Immunoglobulin A vasculitis (IgA-V), formerly called Henoch-Schönlein purpura, is an immune vasculitis. Relapses are frequent (30%) and most of the time cutaneous (90%). Cutaneous involvement in adults is more severe (haemorrhagic blister or necrotic skin lesions) and more extensive than in

A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)

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In each site subjects will be randomized between four arms: artemether-lumefantrine + amodiaquine, artemether-lumefantrine + placebo, artesunate-piperaquine + mefloquine and artesunate-piperaquine + placebo. In Cambodia the comparator will be artesunate-mefloquine due to the current well-documented

Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS

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The investigators selected hospitalized subjects with confirmed or suspected moderate or severe PCP: the diagnostic certainty will be based on the following criteria: Proved PCP. Defined as cases with presence of P. jirovecii cysts in bronchial alveolar lavage (BAL) exams or lung biopsy. Possible

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

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Introduction Onychomycosis caused by non-dermatophyte molds (NDMs) have become more common in clinical practice, particularly in tropical and subtropical area. With worldwide prevalence as high as 10-24% for nail infection, more recent studies have focused on the treatment regimens for NDMs

Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

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Primary oral infection with the herpes simplex virus (HSV) typically occurs at a young age, is asymptomatic, and is not associated with significant morbidity. After primary oral infection, HSV may persist in a latent state in the trigeminal ganglion and later reactivate as the more common herpes

The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.

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Uterine fibroids are the commonest benign gynecological tumors in pre-menopausal women affecting over 80% of African women by age of 50. Myomas are clinically apparent in approximately 12 to 25% of reproductive age women and noted coincidentally on pathological examination in approximately 80% of

Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death

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other data elements, such as eligibility criteria or outcome measures. (Limit: 32,000 characters) Project title: Pre-delivery administration of azithromycin to prevent neonatal sepsis and death: a phase III double-blind randomized clinical trial Acronym: PregnAnZI-2 LIST OF INVESTIGATORS Chief

Maraviroc to Augment Rehabilitation Outcomes After Stroke

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Background After stroke, the combination of progressive skills practice in an adequate dose, exercise for fitness, and reduced sedentary time will augment motor and cognitive outcomes. Sensorimotor and cognitive improvements after stroke often reach a general plateau by approximately 12 weeks after

Probiotics for Modic Changes in Low Back Pain Patients

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Background information on trial preparation The bacteria Lactobacillus rhamnosus GG is an anaerobic gram-positive rod that among other areas exists as a part of the body's normal intestinal flora. In the intestine the bacteria breaks down carbohydrates to form lactic acid. The bacteria is tolerant

Etiology of Eczema Herpeticum (EH)

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This study uses whole genome sequencing (WGS) technology to identify genetic variants that confer risk of recurrent atopic dermatitis with a history of eczema herpeticum (ADEH+), with ≥3 eczema herpeticum (EH) episodes. A small subgroup of individuals with atopic dermatitis (AD) suffer from

NATIENS: Optimal Management and Mechanisms of SJS/TEN

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Background and Scientific Rationale Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe, life-threatening immunologically mediated adverse drug reactions representing the same disease across a spectrum of severity that affect 60,000 patients per year globally at an

Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children

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Blistering distal dactylitis are very common in children. About 60% are caused by Staphylococcus aureus and some are caused by Group A Streptococcus (GAS) or Streptococcus pyogenes. While these forms have been known for fifty years, few publications are interested in it. Some studies have confirmed

Prophylactic Incisional Care in Obese Women at Cesarean

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Overview of the Proposed Trial This will be a pilot randomized controlled trial. The investigators chose a randomized controlled trial, the 'gold standard' of clinical research design, with the goal of obtaining the highest quality evidence to inform clinical practice. Randomly allocating subjects

Home Management of Malaria and Pneumonia

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An integrated approach of home and community management of malaria and pneumonia may increase the proportion of children receiving prompt treatment; improve child survival as measured by a reduction of the under five mortality rate. To test this hypothesis, a cluster randomised controlled trial will

Compression in Anklefracture Treatment, The CAT-study

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Malleolar fractures Surgical treatment of patients with malleolar fractures imposes a special challenge for orthopaedic surgeons. A typical ankle fracture results in haematoma, sometimes blistering and almost always oedema formation. This postpones the optimal time for surgery. When operating on a

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