bufadienolide/cotyledon

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Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata.

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The approximate LD50 and cumulative effect of 4 bufadienolides, isolated from Cotyledon orbiculata, were determined in guinea-pigs. Two of the bufadienolides proved to be mildly cumulative. One of the mildly cumulative bufadienolides induced subacute intoxication with some signs of krimpsiekte when

An outbreak of Cotyledon orbiculata L. poisoning in a flock of Angora goat rams.

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An acute outbreak of C. orbiculata L. poisoning in a flock of 16 Angora Goat rams is described. Typical signs of acute bufadienolide cardiac glycoside toxicity were manifested and 6 animals died. In the 2 animals examined histopathologically multiple foci of myocardial degeneration and necrosis were

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