The concentration of 1.-4 mum airborne particles and the protease content of the airborne dust measured in the cardrooms of ten cotton mills were found to correlate with byssinosis prevalence. Airborne proteases were found in abundance also in wool mills where byssinosis does not occur.
We have previously demonstrated an association between development of the cotton lung disease byssinosis and endotoxin concentrations in the work environment. Endotoxin has been shown to exert its effects through granulocyte activation and hence release of elastase and other proteases at the
The level of IgG, IgA, IgM, alpha1-antitrypsin and alpha2-macroglobulin was determined by radial immunodiffusion in 27 workmen in the flax processing industry, exposed to the risk of byssinosis and 33 retired workmen with a diagnosis of byssinosis. The control lot included 26 blood donors. A
Others have found proteolytic activity in cotton dust and correlated this with the prevalence of acute byssinosis. The present study characterized the proteases in aqueous extracts of cotton dust after controlling for potential artifact from microbial contamination. We tested cotton dust, generated
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