callilepis laureola/necrosis

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The clinical syndrome of Impila (Callilepis laureola) poisoning in children.

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The administration of herbal medicines made from Callilepis laureola is common among the Black population in Natal. This practice can and does cause poisoning, which has only been diagnosed with any confidence at postmortem examination, where the characteristic hepatic and renal tubular necrosis is

Toxicity of Callilepis laureola.

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Callilepis laureola, which has been found to cause fatal liver necrosis in the Black population of Natal, is widely used as a herbal medicine. Chemical extraction has yielded a product, identified as atractyloside, which is responsible for the nephrotoxic and hypoglycaemic effects of Callilepis

The cytotoxic effects of a traditional Zulu remedy, impila (Callilepis laureola).

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The traditional Zulu remedy impila (Callilepis laureola) can cause acute fatal hepatocellular necrosis, especially in children. We investigated the mechanism(s) of toxicity using HuH-7 hepatocytes. Impila tubers were extracted with boiling water and the aqueous extract was used at different

Toxic hepatitis in black patients in natal.

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The clinical and pathological features of toxic centrilobular zonal necrosis in Natal Blacks are described. It is suggested that this condition may be caused by the toxic action of Callilepis laureola (known to the Zulu as 'impila'). This plant and other herbs are used by many Blacks for

Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series.

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BACKGROUND No tabular summary of potentially life-threatening, kidney-toxic dietary supplements (DS; includes herbs) based on PubMed case reports is currently available online and continually updated to forewarn United States consumers, clinicians, and companies manufacturing DS. The purpose of this

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