carapichea ipecacuanha/leukemia

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The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells.

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Emetine, a natural alkaloid from Psychotria ipecacuanha, has been used in phytomedicine to induce vomiting, and to treat cough and severe amoebiasis. Certain data suggest the induction of apoptosis by emetine in leukemia cells. Therefore, we examined the suitability of emetine for the sensitisation

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.

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Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental non-malignant cells for survival. We compared the transcriptomes of primary CLL cells cocultured or not with protective bone marrow stromal cells (BMSCs) and found that oxidative phosphorylation, mitochondrial function, and

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