BRIEF SUMMARY OF THE INVENTION
This invention is concerned with methods of (a) treating arthritis in a mammal by inhibiting the progressive joint deterioration characteristic of arthritic disease, and (b) inducing immunosuppression in a mammal which comprise administering to said mammal an effective
The present invention relates to the use of 2-azabicyclo[2.2.2]octane-3-carboxylic acid derivatives treatment of vascular diseases.
More specifically, the invention relates to the use for the treatment of diseases resulting from impairment of the vascular wall or of disorders of the
The present invention relates to the use of 2-azabicyclo[2.2.2]octane-3-carboxylic acid derivatives for the treatment of vascular diseases.
More specifically, the invention relates to the use, for the treatment of diseases resulting from impairment of the vascular wall or of disorders of the
The examples which follow illustrate the invention and in no way limit the latter.
EXAMPLE 1
ACTIVITY OF THE PRODUCTS OF FORMULA (I) AT NON-HYPOTENSIVE DOSES ON PLASMA CONVERTING ENZYME
The use of a derivative of formula (I) --having converting enzyme inhibitory properties --in the treatment of
BACKGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to novel tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidine compounds that are antagonists of alpha V (.alpha.v) integrins, for example .alpha..sub.v.beta..sub.3 and .alpha..sub.v.beta..sub.5 integrins, their
FIELD OF THE INVENTION
This invention relates to hydroxamic and carboxylic acid derivatives, and to their use in medicine.
BACKGROUND OF THE INVENTION
Metalloproteinases, including matrix metalloproteinase (MMP), collagenase, gelatinase and TNF.alpha. convertase (TACE), and their modes of action,
FIELD OF THE INVENTION
This invention relates to hydroxamic and carboxylic acid derivatives, and to their use in medicine.
BACKGROUND TO THE INVENTION
Metalloproteinases, including matrix metalloproteinase (MMP), collagenase, gelatinase and TNF.alpha. convertase (TACE), and their modes of action,
BACKGROUND OF THE INVENTION
The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment.
The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially
DETAILED DISCLOSURE
This invention pertains to esters and amides of 2,4,6-trialkyl-3-hydroxyphenylalkanoic acids and to organic materials normally subject to oxidative, thermal and UV light deterioration stabilized with said ester and amide compounds. More specifically, the compounds of this
TECHNICAL FIELD
The present invention relates to a surface treated calcium filler for resins and a resin composition containing the filler. The surface treated calcium filler for resins of the present invention has excellent dispersibility, and therefore when added to a porous film, for example,
TECHNICAL FIELD
The present invention relates to an adhesive resin composition which displays excellent initial adhesion and durable adhesion to barrier materials such as saponified products of ethylene-vinyl acetate copolymers, or polyamide based resins, has excellent moldability, and for which
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a soldering flux.
2. Description of the Related Art
The great majority of soldering fluxes heretofore available comprise a rosin or rosin-modified resin supplemented with an activator consisting of an organic acid and a
FIELD OF THE INVENTION
The present invention relates to quinoline derivatives and to the use thereof in therapy. More particularly, the present invention relates to quinoline derivatives for the treatment of cancer, diabetic retinopathy, age-related macular degeneration, inflammation, stroke,
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the U.S. national phase application pursuant to 35 U.S.C. .sctn.371 of PCT International Patent Application No. PCT/JP2012/075482, filed Oct. 2, 2012, which claims priority to Japanese Patent Application No. 2011-227077, filed Oct. 14,
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