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carboxylic acid/inflammation
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Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof
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BACKGROUND OF THE INVENTION
The present invention concerns novel ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory substance having a carboxylic acid function, process for their preparation and pharmaceutical compositions containing them.
The novel esters according to the invention
5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihyd ro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
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BACKGROUND OF THE INVENTION
The present invention relates to novel 5-(2,3-dihydro-1H-pyrrolizin-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]thia zol-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]imidazol-5-oyl)-, and 5-(2,3-dihydro-1H-pyrrolo[2,1-b]oxazol-5-oyl)- derivatives of substituted
5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel 5-aroyl-6-alkylthio, 6-alkylsulfinyl and 6-alkylsulfonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and the pharmaceutically acceptable, non-toxic esters and salts thereof. The invention also relates
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to (i) 5-(4-vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and the pharmaceutically acceptable, non-toxic alkyl esters and salts thereof; (ii) the use of these compounds as
Analgesic and anti-inflammatory 4-OH quinoline carboxylic acid derivatives
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes 4-hydroxy-3-quinoline carboxylic acid derivatives and in particular racemic 4-hydroxy2-1-hydroxypropyl) N-(2-thiazolyl)-8-trifluoromethyl-3-quinolinecarboxamide as having analgesic activity.
OBJECTS OF THE INVENTION
It is an object of the invention
Quinolinoneimine carboxylic acid anti-inflammatory and analgesic composition containing the compound
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TECHNICAL FIELD
This invention concerns a novel compound, a production process therefor and an anti-inflammatory and analgesic composition containing the novel compound.
DISCLOSURE OF INVENTION
This invention concerns 1-(2,6-dichlorophenyl)-2-quinolinoneimine-3-carboxylic acid represented by the
5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents
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BACKGROUND OF THE INVENTION
The present invention relates to novel substituted new 5-(2,3-dihydro-1H-pyrrolizin-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]thiazol-5-oyl)-, 5-(2,3-dihydro-1H-pyrrolo[2,1-b]imidazol-5-oyl)-, and 5-(2,3-dihydro-1H-pyrrolo[2,1-b]oxazol-5-oyl)-pyrrole-2-alkanoic acid
4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes racemic 4-hydroxy-2-(1-hydroxypropyl)-N-(2-thiazolyl)-8-trifluoromethyl-3-quinolin e-carboxamide as having analgesic activity.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their salts with
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
Method and compounds for reducing dermal inflammations
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the treatment of indolent dermal irritations. More specifically, it concerns treatment of persistent inflammations such as chemical ulcers, herpes ulcers, radiation burns, psoriasis and sunburn.
2. General Background of
Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
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BACKGROUND OF THE INVENTION
A group of novel sulfonyl or carbonyl inositol (PI) derivatives are found to be effective phospholipase C inhibitors which are useful anti-inflammatory and analgesic agents.
Phospholipase C contained in mouse peritoneal macrophages has been linked to the enhanced turnover
Esters of the carboxylic acid
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BACKGROUND OF THE INVENTION
2-(p-Prenylphenyl)propionic acid (TA-60) described in U.S. Pat. No. 4,251,543 is a very useful anti-inflammatory and analgesic agent as are 2-(p-isobutylphenyl)propionic acid (ibuprofen) and 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid (naproxen).
SUMMARY OF THE
Pyrazolo [1,5-a]pyrido[3,2-e]pyrimidine-7-carboxylic acid heterocyclic derivatives
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SUMMARY OF THE INVENTION
This invention relates to new derivatives of pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7carboxylic acids and salts thereof. These new compounds have the general formula ##STR2##
The symbols have the following meanings in formula I and throughout this specification:
R, r.sup.1
Catechol carboxylic acids
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BRIEF DESCRIPTION OF THE INVENTION
The invention relates to catechol carboxylic acid derivatives of the formula ##STR7## wherein R.sub.1 is ##STR8## hydrogen, acetyl, hydroxy or alkanoyloxy, R.sub.2 is ##STR9## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or
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