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cardiomyopathies/obesity
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Compounds and methods for treating insulin resistance and cardiomyopathy
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BACKGROUND
All publications mentioned herein are cited for the purpose of familiarizing the reader with the background of the invention. Nothing herein is to be construed as an admission that these references are prior art in relation to the inventions described herein.
Although Type 2 Diabetes
Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
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FIELD OF INVENTION
The present invention relates to a method of making novel dipeptidyl peptidase-IV ("DPP-IV`) inhibitor compounds and a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.
BACKGROUND OF
N-acyl amino acid derivatives, a method for the preparation thereof, a pharmaceutical composition and use thereof as anti-allergic, anti-inflammatory and hypolipidemic agents
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The present invention relates to the field of bioorgmic chemistry and concerns N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof, novel processes for synthesis of said compounds as well as pharmaceutical compositions based on them and use thereof in medicine as
N-acylic aminoacid derivatives, method for the production thereof, pharmacological composition and the use in the form anti-allergic, anti-inflammatory and hypolipidemic agents
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The present invention relates to the field of bioorganic chemistry and concerns N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof, novel processes for synthesis of said compounds as well as pharmaceutical compositions based on them and use thereof in medicine as
Methods of screening for compounds which bind G protein-coupled receptors
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the 35 U.S.C. .sctn.371 national stage of PCT application PCT/JP2005/007354, filed Apr. 11, 2005, which claims priority to Japanese patent application No. 116725/2004, filed Apr. 12, 2004. The contents of these applications are incorporated
Tri-salt form of metformin
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RELATED APPLICATION
This application claims priority to U.S. Provisional Application No. 61/669,763, filed Jul. 10, 2012, the contents of which are incorporated herein by reference in its entirety.
BACKGROUND OF THE INVENTION
Diabetes mellitus has become pandemic and according to a forecast by the
Tri-salt form of metformin
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BACKGROUND OF THE INVENTION
Diabetes mellitus has become pandemic and according to a forecast by the World Health Organization, there will be a sharp increase in the number of diabetic patients by the year 2030. This is an ominous forecast, because managing the long-term complications of diabetes,
Tri-salt form of metformin
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BACKGROUND OF THE INVENTION
Diabetes mellitus has become pandemic and according to a forecast by the World Health Organization, there will be a sharp increase in the number of diabetic patients by the year 2030. This is an ominous forecast, because managing the long-term complications of diabetes,
Hexahydropyrroloimidazolone compounds
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PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of European Patent Application No. 11165232.7, filed May 9, 2011, which is hereby incorporated by reference in its entirety.
FIELD OF THE INVENTION
The present invention relates to organic compounds useful for therapy or
Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
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PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of European Patent Application No. 11166437.1, filed May 17, 2011. The entire contents of the above-identified application are hereby incorporated by reference.
FIELD OF THE INVENTION
The present invention relates to organic
Synthetic apelin fatty acid conjugates with improved half-life
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FIELD OF THE INVENTION
The present invention relates to compositions comprising semi synthetic biologic molecules which are bioconjugates of an APJ agonist polypeptide and a fatty acid moiety. In particular, the bioconjugates of the invention, while retaining APJ agonistic activity, exhibit greater
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
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FIELD OF THE INVENTION
The present invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV (hereinafter "DPP-IV"), pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with
Synthetic apelin mimetics for the treatment of heart failure
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size.
FIELD OF THE
Synthetic apelin mimetics for the treatment of heart failure
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size.
FIELD OF THE
Synthetic apelin mimetics for the treatment of heart failure
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size.
FIELD OF THE
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