charybdotoxin/anemone

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Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone.

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ShK-toxin, a 35 residue peptide isolated from the sea anemone Stichodactyla helianthus, was synthesized using an Fmoc strategy and successfully folded to the biologically active form containing three intramolecular disulfide bonds. The ability of synthetic ShK toxin to inhibit specific

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