cholera/fever

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CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera

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Cellular Immune Responses in Typhoid Fever Patients and Vaccinees

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Description of the Research Project: It has been previously shown that IFN-gamma and IL-17 are increased in typhoid fever patients. It was shown that S. Typhi infection induces antibody responses against a number of key typhoid antigens (LPS) HlyE, Flagellar protein FliC and chaperon protein EcpD).

Typhoid Conjugate Vaccine Introduction in Navi Mumbai, India

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A new generation of typhoid conjugate vaccines (TCVs) have been shown to be safe and provide long-lasting immunity in children. In India, Typbar TCV Vi-TT (Vi capsular polysaccharide conjugated with tetanus toxoid protein) is manufactured by Bharat Biotech International Limited (BBIL).

Tolerability and Acceptability of Fibersol-2 in Children

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To conduct an exploratory study to understand the digestive tolerability of resistant maltodextrin (Fibersol-2) in young healthy and diarrhea children aged 1-3 years for 30 children at home and 30 children at hospital in phase 1. Additionally, propose to conduct a placebo-controlled, randomized,

Controlled Human Infection for Vaccination Against Streptococcus Pyogenes

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Group A Streptococcus (GAS) is a ubiquitous human pathogen. Its impact begins in early childhood and is felt most by those who have the least. Globally, the health services impact of GAS disease in all its forms is immense and strikes at every level from primary to intensive care. Despite

Follow-up of Pregnant Women After a Mass Vaccination of Oral Cholera Vaccine (ShancholTM) in Nsanje Malawi

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Although there are good reasons for women of reproductive age to participate in interventions that prevent cholera, cholera vaccination programs and studies have generally excluded pregnant women since there is little specific information on the safety of the vaccine during pregnancy. However, there

Studies of Immune Responses to Orally Administered Vaccines in Developing Country

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Research Design and Methods Vaccine field sites and overall study design: Mirpur. The vaccine studies will be carried out at the field site in Mirpur, in urban Dhaka, where oral cholera, ETEC and rotavirus studies as well as amoebiasis studies are being conducted over the last 15 years . For the

Therapeutic Induction of Endogenous Antibiotics

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Study design: A double blind randomized clinical trial with subsequent follow-up. Study Subjects: Adult male and female patients attending the Clinical Research and Service Center (CRSC) of ICDDR,B and Matlab Hospital will be screened for participation in the study. Randomization: According to a

New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects

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It will be a Phase IV surveillance study of adverse effects, particularly symptomatic hyponatraemia associated with routine use of hypo-osmolar ORS solution in the treatment of diarrhoea patients of all ages and of any aetiology in a hospital that admits a large number of diarrhoea

Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children.

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STUDY DESIGN This is a randomized controlled clinical trial. Subjects Inclusion criteria: 1. History of acute watery diarrhoea of <72 hrs. 2. Either sex. 3. Age - 6m to 60 months 4. Some or severe dehydration. 5. Wt for Ht <70% of NCHS median: with or without edema. 6. Dark field examination

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