cholestasis/fever

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Ixazomib, ONC201, and Dexamethasone in Relapsed/Refractory Multiple Myeloma

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Phase I Study Design • Phase I will follow a 3+3 dose escalation design to determine the RPTD of ixazomib in combination with ONC201 and Dexamethasone. The dose escalation rules for the phase I portion of the study are as follows, escalating in cohorts of 3 patients per dose level including a

Antibiotics to Decrease Post ERCP Cholangitis

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OBJECTIVES AND PURPOSE The aim is to determine whether a brief course of antibiotics following therapeutic ERCP can reduce post-ERCP cholangitis in patients for whom antibiotics are not already indicated. STUDY DESIGN The study will be a prospective, randomized trial consisting of 452 patients who

Covered Versus Uncovered SEMS for Palliation of Malignant Biliary Strictures.

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Cancer of the pancreas, gallbladder, or bile ducts is the most common cause of malignant obstruction of the biliary tree. Patients who have unresectable tumors have a dismal prognosis in terms of survival and quality of life. In these cases 5-year survival is less than 2% and palliation, such as the

Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study

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Acute-on chronic liver failure (ACLF) was first described by Japanese researchers in 1995. In 2011, the American Association for the Study of Liver Disease (AASLD) and the European Association for the Study of the Liver (EASL) concluded that the core characteristics of ACLF were multiple organ

Endoscopic Treatment of Biliary Stricture Caused by Chronic Pancreatitis

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All consecutive patients admitted for ERCP and treated for benign biliary stricture caused by chronic pancreatitis are prospectively enrolled in the study. At the initial ERCP, an endoscopic sphincterotomy will be performed and one 10 Fr plastic stent will be inserted for the initial treatment of

Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer

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Hypothesis: Percutaneous biliary stenting is superior to endoscopic stenting in providing successful biliary drainage by 20% in patients with unresectable malignant hilar block due to carcinoma of gall bladder. Background: Malignant biliary obstruction at the liver hilum is caused by a heterogeneous

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