cns stimulant/fatigue

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Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.

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OBJECTIVE Fatigue is a distressing symptom occurring in more than 60% of patients with cancer. The CNS stimulants modafinil and methylphenidate are recommended for the treatment of cancer-related fatigue, despite a limited evidence base. We aimed to evaluate the efficacy and tolerability of

Caffeine affects the vigilance decrement of Trite planiceps jumping spiders (Salticidae).

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In jumping spiders (Salticidae), the vigilance decrement, or decrease in response to a repeated visual stimulus over time, directly parallels that found in humans. Explanations for the vigilance decrement in the human literature are heavily mentalistic and central nervous system (CNS) based, whereas

Pharmacological rationale for the clinical use of caffeine.

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Caffeine is widely consumed in beverages to obtain mild CNS stimulant effects. Long term use produces tolerance to some of the pharmacological effects. Withdrawal of caffeine, even from moderate intake levels, can produce symptoms such as headache, fatigue and anxiety. Caffeine is used

[Comparative effectiveness of different biologically active compounds during physical loading].

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Over 30 drugs and recipes were assessed in 440 provocative bicycle ergometry tests (PWC170) and individual tolerance (IT) tests proposed by the authors in which 63 healthy volunteers participated. In the study the IT test was physiologically substantiated, and performance evaluation based on PWC170,

The use of stimulant medications for non-core aspects of ADHD and in other disorders.

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Psychostimulants play a central role in the management of ADHD. Here we review the evidence pertaining to the use of methylphenidate, dexamphetamine and related amphetamine salts, the prodrug lisdexamfetamine and modafinil for the management of comorbid ADHD and non-ADHD indications. There is a

Methylphenidate : a treatment for Parkinson's disease?

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Parkinson's disease (PD) affects about 1 % of the population over the age of 60 years and is characterized by a combination of rest tremor, bradykinesia, rigidity, postural instability, stooped posture and freezing of gait (FoG). However, the clinical spectrum also spans a wide range of non-motor

A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy.

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OBJECTIVE The quality of life (QOL) and neurocognitive function of patients with brain tumors are negatively affected by the symptoms of their disease and brain radiation therapy (RT). We assessed the effect of prophylactic d-threo-methylphenidate HCl (d-MPH), a central nervous system (CNS)

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