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7 results
Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one
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BACKGROUND OF THE INVENTION
Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii) neuronal fate determination of NSC; (iii) survival and maturation of new neurons; and (iv) functional
1,7-naphthyridine derivatives
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of International Application No. PCT/EP2014/066123 having an international filing date of Jul. 28, 2014 and which claims benefit under 35 U.S.C. .sctn.119 to European Patent Application No. 13178373.0 filed Jul. 29, 2013. The
Benzisoxazoles
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BACKGROUND OF THE INVENTION
Now it has been shown that the present compounds stimulate neurogenesis from neural stem cells (NSCs). Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii)
Imidazopyridine derivatives
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The present invention relates to compounds of general formula
##STR00002## wherein Ar is phenyl or pyridinyl; X.sup.1 is N or CH, X.sup.2 is N or CH, with the proviso that only one of X.sup.1 or X.sup.2 is N and the other is CH; R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl
Isoquinoline derivatives
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The present invention relates to the use of compounds of general formula
##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is
Pyrido[4,3-B]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders
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FIELD OF THE INVENTION
The present invention relates to novel compounds of formula I, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as described herein, having pharmaceutical activity, their manufacture, pharmaceutical compositions containing them and their potential use as
Benzimidazoles as CNS active agents
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The present invention relates to compounds of general formula
##STR00002## wherein R.sup.1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R.sup.2 is hydrogen or halogen; X.sup.1 is N or CH; X.sup.2 is N or CH; with the proviso that only one of X.sup.1 or X.sup.2 is N; X.sup.3
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