cocaine/fatigue

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Dopaminergic involvement during mental fatigue in health and cocaine addiction.

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Dopamine modulates executive function, including sustaining cognitive control during mental fatigue. Using event-related functional magnetic resonance imaging (fMRI) during the color-word Stroop task, we aimed to model mental fatigue with repeated task exposures in 33 cocaine abusers and 20 healthy

Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: no correlation with fatigue and sleepiness.

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BACKGROUND Fatigue and sleep disturbance are common features of multiple sclerosis (MS). Our objectives were to determine cerebrospinal fluid levels of orexin A (hypocretin-1), a hypothalamic peptide involved in sleep, in patients with MS, and correlate them with fatigue, sleepiness, and levels of

Observations on the effects of chewing cocaine wax or coca leaves on muscular fatigue.

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Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity.

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Trait impulsivity has been linked to addiction in humans. It has been suggested that drug users with high trait impulsivity levels are more sensitive to subjective drug intoxication. This study assessed whether subjective response to drugs differs between drug users with normal or high levels of

Symptoms Suggestive of Dysphagia and the Quality of Life in Cocaine and/or Crack Users.

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Users of cocaine and/or crack may present symptoms of dysphagia due to changes in anatomical structures caused by the use of these substances. The objective of this study was to investigate the presence of symptoms suggestive of dysphagia in users of cocaine and/or crack seeking treatment, as well

Dopamine agonists for cocaine dependence.

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BACKGROUND Cocaine is a major drug of abuse. Cocaine dependence is a common and serious condition, which has become nowadays a substantial public health problem. There is a wide and well documented range of consequences associated to chronic use of this drug, such as medical, psychological and

Adolescent cocaine abuse. Addictive potential, behavioral and psychiatric effects.

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Four hundred seventy-nine drug abusing adolescent patients enrolled in seven Straight, Inc. Adolescent Drug-Abuse Treatment Programs in five geographic regions across the United States were studied to determine the severity and patterns of cocaine abuse. Of these, 341 admitted to cocaine use and

Effect of various doses of cocaine on endurance capacity in rats.

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To determine the effects of a variety of doses of cocaine on endurance capacity, rats were injected intraperitoneally with either 0.1, 0.5, 2.5, 12.5, or 20 mg/kg body wt 20 min before running to exhaustion at 26 m/min up a 10% grade. Animals given saline ran 116 +/- 9 (SE) min. At doses of 12.5 and

Effects of cocaine on glycogen metabolism and endurance during high intensity exercise.

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Because cocaine causes a rapid sympathetic response and central euphoria, we tested whether it would improve endurance or alter carbohydrate metabolism during high-intensity activity. Thirty male rats (10 animals/group) were injected intraperitoneally with either saline (S) or one of two doses of

Improved performance 4 hours after cocaine.

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Cocaine (2 mg/kg) was given orally to 13 healthy volunteers and physiologic, subjective, attentional and performance effects were measured over a period of 4 h. Posner's reaction time paradigm measured the effects of cocaine on performance and on attention to visual cues. Cocaine increased heart

Chronic cocaine exposure in the SCID mouse model of HIV encephalitis.

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Clinical and preclinical evidence suggests that cocaine exposure hastens progression of the HIV disease process. An established active, euphoric dose of cocaine (20 mg/kg) was administered to SCID mice according to a regimen consistent with exposure to the drug by cocaine-abusing HIV-infected

A comparison of self-reported symptoms and DSM-III-R criteria for cocaine withdrawal.

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The frequencies of 15 self-reported symptoms of cocaine withdrawal were compared in 75 subjects to the symptoms listed as criteria by DSM-III and DSM-III-R for either amphetamine or cocaine withdrawal. Three of the four most frequently reported symptoms, depression (75%), sleep disturbance (71%),

The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice.

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BACKGROUND Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns. OBJECTIVE What are the common and serious side effects of disulfiram in cocaine-dependent individuals with

[Fatigue in substance abuse disorders].

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Fatigue is a common symptom in substance abuse disorders. The most frequent and relevant addiction disorders like alcoholism and dependence of illegal drugs like THC, opioids, cocaine, ecstasy, psycho-stimulants, and GHB/GBL (gamma hydroxybutyrate/gamma butyrolactone; "Liquid Ecstasy") are

Dopamine agonists for cocaine dependence.

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BACKGROUND Cocaine dependence is a common and serious condition, which has become nowadays a substantial public health problem. There is a wide and well documented range of consequences associated to chronic use of this drug, such as medical, psychological and social problems, including the spread

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