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15 results
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
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Design: Randomized treatment control trial, double-blind, parallel, with two arms.
Sample: Ninety-six hospitalized women between 18 and 52 years will participate in this study. Those who agree to participate in the study and meet the eligibility criteria will be randomly allocated to one of the
Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder
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Lorcaserin is a serotonin (5-HT) 2C receptor agonist (Trade Name Belviq) approved for treatment of obesity. The study teams's preclinical research collaborators and others have shown that lorcaserin and other 5-HT2CR agonists have been shown to reduce drugs of abuse self-administration and cue
Transcranial Magnetic Stimulation (TMS) in Obesity
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Native Women's Wellness: Contingency Management for Tobacco Cessation and Weight Loss
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American Indians and Alaska Native (AI/AN) people experience striking disparities in mortality from cardiovascular disease compared to the general U.S. population. Among women of childbearing age, early detection of chronic diseases can be missed because the type of medical care they seek is
Lorcaserin Intra Venous Cocaine Effects
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Background
Serotonin (5-HT) is one of three brain monoamines that are widely distributed in the brain and play important roles in affect and goal-directed behaviors. Limbic structures that underlie behavior motivated by palatable food and drugs of abuse receive dense projections from brainstem
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
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The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self-administration data) in non-treatment seeking cocaine use disorder subjects. This project will provide
Gauging Of Light Dependent Experiences Through Neuroimaging (GOLDEN)
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UV radiation has recently been classified as a known human carcinogen by the US Department of Health and Human Services. Nevertheless, the voluntary exposure to sunlight continues unabated despite progressively increasing rates of ultraviolet radiation (UVR)-induced illness and death, particularly
A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence
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Cocaine (COC) dependence is a significant public health concern. A widely effective pharmacotherapy has not yet been identified for COC dependence. Innovative strategies are needed to identify an effective pharmacotherapy for COC dependence. Testing medications effective for disorders that share
"Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): A Randomized Control Trial in Chilean Primary Care."
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Long-term Phentermine Pharmacotherapy: An Investigation for Symptoms of Dependence, Cravings, or Withdrawal
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Perforated Marginal Ulcer After Gastric Bypass
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The epidemic of overweight and obesity in the United States of America along with its comorbidities continues to expand. Bariatric surgery has demonstrated to be the most effective and sustained method to control severe obesity and its comorbidities. For instance, type 2 diabetes mellitus was
Chronic Marginal Ulcers After Gastric Bypass
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The epidemic of overweight and obesity in the United States of America along with its comorbidities continues to expand. Bariatric surgery has demonstrated to be the most effective and sustained method to control severe obesity and its comorbidities. For instance, type 2 diabetes mellitus was
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
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The most recently available statistics indicate that approximately 22.2 million people in the United States have asthma. Of these, about 55% experienced at least one attack in the year before the survey resulting in 1.9 million visits to emergency departments and 497,000 hospitalizations. The
Smoking Cessation for Veterans With Severe and Persistent Mental Illness
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Smoking is the leading cause of preventable death in the United States. Smoking contributes to increased rates of diseases such as lung cancer and heart disease, and adds dangerous complications to health problems such as diabetes and obesity. Despite widespread recognition of the devastating health
The Effects of Rimonabant, on Weight and Metabolic Risk Factors
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Part I will be a 2-week evaluation phase. In Part I, subjects undergo a diagnostic interview for symptoms and treatment along with medical, side effect measures, and neuropsychological tests (tests for memory, attention, and motor task skills). An electrocardiogram (EKG), a urine sample, and about 3
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