codeine/hepatitis

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[Acute cholestatic hepatitis induced by dextromethorphan].

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A case of a 68-years-old female who was symptomatically treated with the codeine analog dextromethorphan because of a flu-like syndrome is herein reported. Five days later, she developed a cholestatic syndrome without fever or abdominal pain. Dextrometorphan was withdrawn and a rapid clinical

[Acral erythema and HIV infection].

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BACKGROUND Acral erythema is a non specific skin condition observed in connective tissue diseases, viral infections and toxic skin reactions. More recently, this symptom has been reported in HIV-infected patients. METHODS We observed two cases of acral erythema in HIV seropositive patients. Both

Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry.

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Oxymatrine (OMT) and matrine (MT) are the major quinolizidine alkaloids found in certain Sophora plants, which have been extensively used in China for the treatment of viral hepatitis, cancer, cardiac diseases and skin diseases (such as atopic dermatitis and eczema). A precise, sensitive and high

[Nutritional status of drug addicts in a methadone program].

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BACKGROUND Substitution treatment of drug addicts with methadone has been used in many countries for more than 35 years. In our country it was started in 1997. The objective was above all to evaluate the nutritional status and some biochemical parameters before and after 18 months of methadone

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury

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The opioids are a large class of medications related in structure to the natural plant alkaloids found in opium that are derived from the resin of the opium poppy, Papaver somniferum. The natural alkaloids are also referred to as opiates and include morphine and codeine. Synthetic derivatives

[Two years follow-up of a heroin users cohort treated with high dosage buprenorphine. Results of the SPESUB study (pharmacoepidemiologic follow-up of general practice Subutex)].

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BACKGROUND Since February 1996, French GPs are allowed to prescribe high dosage buprenorphine for maintenance treatment of major opioid drug addiction. A prospective cohort of major opioid addicts was initiated in order to assess patient outcomes: follow-up, retention rate in treatment, drug use,

Sleep-related eating disorders: polysomnographic correlates of a heterogeneous syndrome distinct from daytime eating disorders.

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Over a 5-yr period, 19 adults presented to our sleep disorders center with histories of involuntary, nocturnal, sleep-related eating that usually occurred with other problematic nocturnal behaviors. Mean age (+/- SD) at presentation was 37.4 (+/- 9.1) yr (range 18-54); 73.7% of the patients (n = 14)

Selection of WHO-recommended essential medicines for non-communicable diseases on National Essential Medicines Lists.

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Non-communicable diseases (NCDs) are the leading cause of death worldwide. Inadequate and inequitable access to essential NCD medicines is a major concern, particularly in low- and middle-income countries. National Essential Medicines Lists (EMLs) are important policy tools that

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