codeine/inflammation

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Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid

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PROJECT TEAM N.Fusun Toraman (NFT) cell phone: +90 505 355 9045 e.mail: fusuntoraman@gmail.com Meral Bilgilisoy Filiz (MBF) cell phone: +90 505 647 5840 e.mail: mbilgilisoy@gmail.com Aslı Karadag Ozdemir (AKO) cell phone: +90 555 276 6334 e.mail:aslikaradagoz@gmail.com Yasemin Karaman (YK) cell

Arthroscopic Versus Open Brostrom for Ankle Instability

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1. Introduction Ankle sprains are among the most prevalent lesions in the athletic and non-athletic population(1). Accounting to up than 14% of emergency visits and with an estimated year cost of more than U$6 billion, it has a high impact in the health care system(2,3). Approximately 10 to 40% of

A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty

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The study will be performed in Participants diagnosed with OA of the knee who are scheduled for arthroplasty of the knee as a treatment for their OA. Approximately fifty (50) male and female OA participants, who, at the time of screening, are ≥50 years old, will be randomized in a 2:1 ratio: two

Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy

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Pediatric tonsillectomy is one of the most common surgical procedures in the United States, with over 500,000 procedures performed annually.1,2 The most common indications for tonsillectomy with and without adenoidectomy are sleep-disordered breathing and recurrent tonsillitis, though significant

Electroacupuncture for Acute Pancreatitis

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Acute pancreatitis (AP) causes significant abdominal pain, which can destroy patients'quality of life. Most patients have associated nausea and vomiting. Pain control for such patients is the mainstay of AP management. Opioids are safe and effective for pain control in patients with AP. Compared

Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome

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Hypothesis A course of amoxicillin (250 mg ,three times daily for five days), routinely prescribed as a part of treatment protocol for third molar extractions causes a significant shift of the stable oral microbiome . The primary outcome measures are to assess: 1. Relative abundance of different

Multimodal Pain Management for Cesarean Delivery

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We are proposing a double-blinded, placebo controlled, randomized trial of patients undergoing elective cesarean delivery. Participants will be randomized to either a control group or study group. This is a double-blinded study, neither participants nor the obstetric or anesthesia team are aware of

Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain

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The aim of this study was to measure pain during PRK postoperative period, comparing placebo with the association of codeine phosphate 30 mg and paracetamol 500 mg for 72h after surgery. This is a double-blind, prospective, randomized study involving 80 eyes of 40 patients (paired design), who

Post-operative Pain Control After Pediatric Adenotonsillectomy

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Post-operative pain management in pediatric patients undergoing adenotonsillectomy is challenging not only for the child, but also for the clinician and caregiver. Uncontrolled pain carries a high level of morbidity and can result in prolonged hospital stay and/or readmission, dehydration, weight

Patient-Controlled Epidural Analgesia After Uterine Artery Embolization

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The investigators hypothesize that the use of a patient-controlled lumbar epidural analgesia (PCEA) will reduce pain scores and improve patient's satisfaction after uterine artery embolization. The present study is aiming to compare the efficacy of PCEA and continuous epidural infusion of

Treatment of Chronic Pain From Osteoarthritis

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The WHO analgesic ladder, even with its limitations, is widely used to guide the beginning of opioid therapy in chronic pain. According to this approach the choice of drug is based on the intensity of pain reported by the patient; belong to the first step acetaminophen and nonsteroidal

Study of Analgesics Drug and Human Milk Transfer in Mature Milk, to Avoid Breastfeeding Cessation Without Scientific Probes

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Analgesics are frequently used to prevent and treat pain and inflammatory disease. Due to a lack of information on drug's human milk transfer, breastfeeding is sometimes contraindicated. Mothers are advised to either stop breastfeeding or if they don't, not to treat themselves. Since the fatal

Safety Study of Post Tonsillectomy Ibuprofen Use in Adults

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Tonsillectomy is common procedure associated with significant post-operative pain typically managed by narcotic pain medication. Narcotics, however, can have inherent unwanted side effects such as respiratory depression. In fact, a recent U.S. Food and Drug Administration (FDA) warning has reported

Investigating the Safety of Post-surgical Analgesics in Children With Obstructive Sleep Apnea

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Drug Interactions Between Paracetamol and Setrons in Pain Management

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Tonsillectomy is a common operation performed in children that is associated with marked pain and a high incidence of nausea and vomiting. Therefore, national and international guidelines have recommended the use of a setron as a prevention to nausea and vomiting and also the systematic

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