colchicine/diarrhea

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Vomiting, diarrhea, and sudden death with recent southeast asian travel : Fatal colchicine toxicity.

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A 41-year-old male was referred for autopsy from a hospital with a diagnosis of sepsis of uncertain etiology. As he had recently been attached to a military base in Southeast Asia, and had only just returned home, there was considerable concern that an unknown infectious agent may have been

'Until diarrhea occurs'? There's a maximum dosage to prevent colchicine toxicity.

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Gastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (familial mediterranean fever).

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Twelve patients with recurrent polyserositis (RP, familial Mediterranean fever) on colchicine prophylaxis (1.0-2.0 mg daily) for three years or more were evaluated for the presence of gastrointestinal effects possibly attributable to the drug. Two patients had bulky stools, two others had transient

Colchicine exposures: the Texas experience.

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OBJECTIVE Colchicine is a relatively uncommon toxin, but is known to precipitate severe multiorgan failure in overdose. Little is known about exposure patterns and outcomes in cases of colchicine ingestion. Our goal was to add to toxicologic knowledge through a database review and descriptive study

Treatment of chronic urticaria with colchicine.

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BACKGROUND Chronic urticaria (CU) is a cutaneous disease that can be debilitating, difficult to treat, and sometimes life-threatening. Treatment with antihistamines is often ineffective. Immunosuppressants are second line therapy but can have significant side effects. Data is needed on effective

Death following colchicine poisoning.

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A 45-year-old male was admitted to hospital after 2 to 3 days of vomiting, nausea, and diarrhea following an apparent overdose of colchicine tables. During hospitalization his white blood cell count fell dramatically. At death, 33 h following initial hospitalization, pleural effusion with bilateral

Acute colchicine intoxication complicated with complete AV block.

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Colchicine, is an old and well-known drug, used for treatment of rheumatic diseases. Nausea, vomiting, abdominal pain, and diarrhea are the clinical symptoms of colchicine poisoning. Cardiotoxicity can lead to mortality. We report a case of colchicine intoxication complicated with complete heart

Hepatobiliary excretion and enterohepatic circulation of colchicine in rats.

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This study investigated the pharmacokinetics of unbound colchicine in rat blood, liver and bile, and its interaction with cyclosporin A (CsA; P-glycoprotein inhibitor) and proadifen (non-specific cytochrome P450 inhibitor) by using a microdialysis and liquid chromatographic system. The

Fatal i.v. colchicine injection in a 60-year-old woman.

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Colchicine is a rather benign drug when used appropriately and with an understanding of its potential side effects and toxicity. However, colchicine toxicity, though uncommon, is life-threatening. It is especially devastating to geriatric or debilitated patients because of its cumulative effects.

Hemophagocytic lymphohistiocytosis and pelger-huët anomaly associated with colchicine intoxication.

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Colchicine is frequently used in the treatment of familial Mediterranean fever (FMF). First symptoms of colchicine intoxication are gastrointestinal disturbances, such as abdominal cramps, diarrhea, pancytopenia and so on. Herein, we report a female FMF patient with pancytopenia and hemophagocytic

Treatment of severe recurrent aphthous stomatitis with colchicine.

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Recurrent aphthous stomatitis (RAS) is characterized by necrotizing ulcers of the oral mucosa that persist, remit, and recur for variable periods of time. Despite the benign nature of the disease, persistent pain and ulceration may disable patients from performing their daily activities. We describe

Colchicine poisoning complicated by medulla oblongata myelinolysis: a case report

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Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an

Survival case of colchicine intoxication following ingestion of a lethal dose.

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BACKGROUND There have been few reports of cases where the ingestion of colchicine was utilized as a method of suicide and accordingly, its effect on the human body is not fully understood. It has been reported that all individuals who ingested more than 0.8 mg/kg of colchicine died of shock within

Epithelial cell mitotic arrest--a useful postmortem histologic marker in cases of possible colchicine toxicity.

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Following ingestion of 30 mg of presumed benztropine (Cogentin) a 39-year-old male developed nausea, vomiting and diarrhea. His admission to hospital was soon followed by collapse and death. Histological examination, however, revealed increased numbers of mitotic figures in otherwise normal

Treatment of pustulosis palmaris et plantaris with oral doses of colchicine.

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The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to

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