colchicine/obesity

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Reversible hyperphagia and obesity following intracerebral microinjections of colchicine into the ventromedial hypothalamus of the rat.

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Colchicine, a drug which produces a reversible inhibition of intraaxonal transport and synaptic transmission, was used as a reversible neural blocker to investigate the role of the ventromedial hypothalamus (VMH) in the control of ingestive behavior and body weight regulation. Male Sprague-Dawley

Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.

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Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state.

[The effect of colchicine, heavy water and cytochalasin B on adipose tissue metabolism in normal and obese, hyperglycemic mice].

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Development of acute gouty attack in the morbidly obese population after bariatric surgery.

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BACKGROUND Gout is associated with increased body weight. We evaluated the prevalence of gout and acute gouty attacks in the morbidly obese population who underwent bariatric surgery. METHODS The medical records and operative reports of 1,240 patients who underwent bariatric surgery were reviewed

[Sarcoidosis and obesity].

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BACKGROUND Polypliagia and morbid obesity appears in patients with sarcodosis may be signs of neurosarcoidosis in the medial hypothalmus where satiety center is located. It is estimated that about 1% of all patients with sarcoidosis may have sarcoidosis of the hxpothalamus. It is of utmost

Colchicine Intolerance in FMF Patients and Primary Obstacles for Optimal Dosing

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Aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice, it is not easy to maintain effective colchicine doses in substantial number of patients, due to its side effects. In this study, we aimed to investigate prevalence and risk factors for

Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.

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OBJECTIVE Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory

Rats with hypothalamic obesity are insensitive to central leptin injections.

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Genetically determined obesities, involving leptin- and melanocortin-signaling pathways, have focused attention on the four medial hypothalamic nuclei as primary sources of feeding- and metabolically-based obesity. All four medial cell groups contain leptin receptors. To determine which of these

Neuropeptide Y in the magnocellular hypothalamic neurons of obese Zucker rats.

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The obesity syndrome in Zucker rats is associated with an elevated neuropeptide Y (NPY) content in the hypothalamus. It is recognized that the axons of NPY-ergic neurons arriving from the arcuate nucleus and the midbrain are the major source of NPY in this area. In magnocellular hypothalamic

Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse.

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The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) is an important regulator of feeding behavior. A hypothalamic site of action for 5-HT in body weight control is supported by the presence of 5-HT receptors in hypothalamic regions which are intimately associated with regulation of food

Effects of colchicine in adults with metabolic syndrome: A pilot randomized controlled trial.

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To evaluate the efficacy and safety of colchicine for improving metabolic and inflammatory outcomes in people with obesity and metabolic syndrome (MetS).

MATERIALS AND METHODS

Adults with obesity and MetS, but who did not have diabetes, were randomized

Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial

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Objective: Recent clinical trials have demonstrated that colchicine may have metabolic and cardiovascular and benefits in at-risk patients; however, the mechanisms through which colchicine may improve outcomes are still unclear. We sought to examine colchicine's

Management of hyperuricemia and gout in obese patients undergoing bariatric surgery.

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BACKGROUND Hyperuricemia and gout represent important issues in the obese patients. Considering the epidemic trend of overweight and obesity in developed countries, the impact of these conditions is likely to increase. At present, bariatric surgery represents the most effective treatment for the

A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection

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Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ

Hypothalamic obesity: multiple routes mediated by loss of function in medial cell groups.

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Cell groups of the medial hypothalamus are key to the regulation of energy balance. Functional disruption by colchicine injected in the hypothalamic arcuate (ARC), paraventricular (PVN), and ventromedial (VMN) cell groups produced increased food intake and obesity; disruption of the dorsomedial

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