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7 results
[Deacetyl-N-methylcolchicine, an antimitotic alkaloid of Colchicum autumnale, in therapy of leukemia and Hodgkin's disease].
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Treatment of chronic myeloid leukaemia with a colchicum derivative.
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[A new Colchicum-secondary alkaloid (Demecolcin Ciba) as cystostatic in myelocytic leukemias].
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[Leukemia and cancer treatment with a new alkaloid from Colchicum autumnale; demecolcin].
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Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.
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Colchicine is the major alkaloid isolated from the plant Colchicum autumnale, which shows strong therapeutic effects towards different types of cancer. However, due to the toxicity of colchicine towards normal cells its application is limited. To address this issue we synthesized a series of seven
A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells.
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Colchicine, an antimitotic alkaloid isolated from Colchicum autumnale, is a classical drug for treatment of gout and familial Mediterranean fever. It causes antiproliferative effects through the inhibition of microtubule formation, which leads to mitotic arrest and cell death by apoptosis. Here, we
Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure. Interactions with tubulin.
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Cornigerine is a natural product analog of colchicine produced by Colchicum cornigerum in which the vicinal 2- and 3-methoxy groups are condensed into a methylenedioxy bridge. This produces a fourth ring and a structure which resembles a hybrid of colchicine, podophyllotoxin, and steganacin.
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