colonic polyps/hypoxia

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Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer.

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BACKGROUND HIF-1α and CXCR4/CXCL12 have crucial roles in the metastatic process of colorectal cancer. Our aim was to study the significance of targeting HIF-1α and the CXCR4/CXCL12 axis in colorectal cancer to prevent the dissemination process in vitro. METHODS We investigated CXCR4 and CXCR7 mRNA

Genetic basis of cancer of the kidney: disease-specific approaches to therapy.

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Studies during the past two decades have shown that kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in this organ. Clear cell renal carcinoma is characterized by mutation of the VHL gene. The VHL gene product forms a heterotrimeric complex

Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry.

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BACKGROUND Advances in optical and computer technology have enabled the development of a device that uses white-light reflectance spectrophotometry to measure capillary hemoglobin saturation in intestinal mucosa during colonoscopy. METHODS Studies were performed with the colon oximeter in

A prospective analysis of 13,580 colonoscopies. Reevaluation of credentialing guidelines.

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BACKGROUND The aims of this study were to assess the safety and efficacy of surgeons performing colonoscopy, and to use the results to reevaluate currently available credentialing guidelines. METHODS A prospective outcomes study was designed to include all members of the Society of American

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