combretum glutinosum/potassium

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Mechanisms of the antinociceptive action of (-) epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents.

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BACKGROUND The mechanisms of the antinociceptive activity of (-) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher. METHODS were assessed in the model of chemical nociception induced by glutamate (20 μmol/paw). To evaluate the mechanisms

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.

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Combretastatin A-4 (1a), the principal cancer cell growth-inhibitory constituent of the Zulu medicinal plant Combretum caffrum, has been undergoing preclinical development. However, the very limited water solubility of this phenol has complicated drug formation. Hence, derivatives of the

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