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Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia

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The increasing prevalence of dementia is a serious threat to our medical system and our society. About 500,000 Canadians are affected with dementia, and this number will rise to more than 1 million in the next 20 years. Dementia already costs our economy 15 billion dollars per year. While much of

Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients

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Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients (SnPPIX) Official Title: Efficacy of Based MRI Contrast Media Against Covid-19 _____________________________________________________________________________________________

Lidocaine Combined With Low Opioid Anesthesia and Analgesia in Patients With Primary Liver Cancer

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200 patients with primary liver cancer who meet the standard are included. According to the random number, the patients are divided into lidocaine group and conventional analgesia group. Changes in liver and kidney function, blood routine, blood coagulation function and tumor marker

Effects of Perampanel on Neurophysiology Test Perimeters

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The study drug used in this research study is perampanel, an FDA approved medication for the treatment of seizures. The study is being done to examine whether the study drug affects the following non-invasive tests of brain activity: electroencephalogram (EEG), visual evoked potential (VEP),

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

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MATERIALS AND METHODS After approval of the institutional Ethics committee board, written informed consent will be taken from all the eligible and willing patients. A. Study design: Randomized double blind active controlled parallel group noninferiority clinical trial. B. Randomization: A variable

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

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This will be a double-blind, 3-arm, randomized controlled trial with a treatment 1: treatment 2: control allocation ratio of 1:1:1. Primary outcomes of interest are opioid requirements and pain scores over initial 72 hours of the postoperative period. Opioid requirements will be assessed by

A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair

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Participants Selection After obtaining institutional review board approval and written informed consent from all participants, the investigators prospectively enrolled 180 participants scheduled to undergo arthroscopic acromioplasty and rotator cuff repair for a partial or full thickness tear

The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsy

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Specific Aims/Study Objectives This is a pilot study to explore the effects of cannabidiol (CBD) on autonomic cardiac function in children with Dravet syndrome (DS) or Lennox-Gastaut syndrome (LGS) when the CBD is administered as an artisanal oil. This will be achieved by addressing the following

Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders

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BACKGROUND Obsessive‐Compulsive Disorder [OCD] is a psychiatric disorder with a lifetime prevalence of 2% which is mainly characterized by obsessional ideas and compulsive behaviours and rituals. Many patients show improvement under cognitive behavioural and/or pharmacological treatment. A minority

RCT of IV Dexamethasone to Prevent Relapse in the Treatment of Migraine in a Paediatric ED

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Study design This was a randomised, double-blind, placebo-controlled clinical trial among children with a presumptive diagnosis of acute migraine in the ED. The study was approved by the institutional IRB and written informed assent and consent were obtained by the patient and a parent respectively,

Biomarker for Hypophosphatasia Disease (BioHypophos)

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Hypophosphatasia (HPP) is a rare genetic disorder characterized the abnormal development of bones and teeth. These abnormalities occur due to defective mineralization, the process by which bones and teeth take up minerals such as calcium and phosphorus. These minerals are required for proper

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

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BACKGROUND, SIGNIFICANCE, AND RATIONALE Failure to thrive or inadequate weight gain is a frequent complaint amongst patients seen by general pediatricians and pediatric gastroenterologists. The reasons behind this diagnosis vary widely including, but not limited to feeding disorders of diverse

A Double Blind, Randomized, Placebo Controlled, Crossover Study of the Effectiveness of Oral Fampridine in Improving Upper Limb Function in Progressive Multiple Sclerosis

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BACKGROUND INFORMATION Patients with secondary progressive MS (SPMS) and primary progressive MS (PPMS) have significant walking disability and impaired upper limb function due to repeated demyelination and axonal injury affecting the corticospinal pathways. In some patients this motor deficit may be

Phase I Gene Therapy Clinical Trial Using the Vector rAAV2/5-PBGD for the Treatment of Acute Intermittent Porphyria

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Acute Intermittent Porphyria (AIP) is inherited as an autosomal dominant disorder of the heme biosynthesis pathway. AIP is caused by a genetic defect in porphobilinogen deaminase (PBGD), a key enzyme for heme synthesis. AIP is characterized by acute episodes and asymptomatic periods. Neuropathic

Observational Study of Acute Intermittent Porphyria Patients

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Acute Intermittent Porphyria (AIP) is inherited as an autosomal dominant disorder of the heme biosynthesis pathway. AIP is caused by a genetic defect in porphobilinogen deaminase (PBGD) a key enzyme for heme synthesis. AIP is characterized by acute episodes and asymptomatic periods. Neuropathic

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