corynoline/corydalis incisa

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Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase.

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In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE

[Studies on the alkaloids of papaveraceous plants. XXVII. The C1-units of corynoline, the major alkaloid from Corydalis incisa Pers (author's transl)].

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Benzo[c]phenanthridine alkaloids from Corydalis incisa.

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Six benzo[c]phenanthridine alkaloids, corynoline (1), acetylcorynoline (2), corynoloxine (3), luguine (4), 6-oxocorynoline (5), and 12-hydroxycorynoloxine (6) were isolated from the aerial parts of Corydalis incisa, and 6 was isolated for the first time from nature. The structure was elucidated by

Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa.

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Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and

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