crocetin/hemorrhage

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Protective effect of crocetin on hemorrhagic shock-induced acute renal failure in rats.

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Multiple organ failure is a common outcome of hemorrhagic shock followed by resuscitation, and the kidney is one of the prime target organs involved. The main objective of the study was to evaluate whether crocetin, a natural product from Gardenia jasminoides Ellis, has beneficial effects on renal

Effect of crocetin on blood pressure restoration and synthesis of inflammatory mediators in heart after hemorrhagic shock in anesthetized rats.

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Crocetin, a constituent of saffron, has been shown not only to prevent reactive oxygen species-induced hepatotoxicity and genotoxicity but also to increase whole-body oxygen consumption and survival. The present study was to determine whether crocetin has beneficial effects on cardiac injury caused

The effect of crocetin on hemorrhagic shock in rats.

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There is a reduction in oxygen consumption during hemorrhagic shock, and it has been suggested that this correlates with mortality. Recent data indicate that the consumption of oxygen may depend on its diffusion from the erythrocytes to the mitochondria; thus, enhancing this rate might increase

Molecular basis of protective effect by crocetin on survival and liver tissue damage following hemorrhagic shock.

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Hemorrhagic shock (HS) causes reduction of cellular energy stores, as measured by levels of ATP and ADP. Furthermore, energy depletion may cause mitochondrial damage, which in turn leads to cell death by apoptosis. The hypothesis of the present study is that by enhancing the recovery of cellular ATP

Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock.

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BACKGROUND Hemorrhagic shock results in cellular damage and cell death. A primary mechanism is cellular apoptosis from mitochondrial damage. This study demonstrated that administration of crocetin to experimental animals during resuscitation from shock significantly improved postshock survival and

Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock.

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BACKGROUND Inflammatory factors play an important role in cellular damage after shock and resuscitation. Crocetin, a saffron-derived carotenoid, has been shown to improve postshock recovery of cellular adenosine triphosphate (ATP) and to increase overall survival in an experimental model of

Carotenoid compound crocetin improves cerebral oxygenation in hemorrhaged rats.

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The carotenoid compound crocetin has been shown to increase oxygen diffusivity in vitro. In the present study the effect of crocetin on tissue oxygenation was examined in the cerebral cortex of rats subjected to hemorrhage. Twelve male Sprague-Dawley rats were anesthetized with pentobarbital and

Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cells.

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BACKGROUND This is a review of studies with two agents, glutamine and crocetin, which have been found to enhance recovery of cellular adenosine triphosphate (ATP) and adenosine diphosphate after hemorrhagic shock. METHODS The studies used a sublethal (30 minutes) reservoir shock model in 300- to

Trans-sodium crocetinate does not affect oxygen uptake in rats during treadmill running.

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Trans-sodium crocetinate (TSC), the isomer of the carotenoid compound crocetin, is found markedly to increase survival in hemorrhagic shock subsequent to 50-60% blood loss, mainly via restored resting oxygen consumption (VO(2)), blood pressure and heart rate. The proposed mechanism is that TSC

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