cutis laxa/edema

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Bilateral eyelid edema: cutis laxa or blepharochalasis?

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A 59-year-old woman with massive bilateral edema of the upper and lower eyelids is presented. The edema occurred suddenly and without provocation. No cause could be identified despite a multitude of examinations. Initially the patient was diagnosed as having blepharochalasis, but later skin biopsy

[Acquired cutis laxa (elastolysis generalisata)].

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Following glomerulonephritis with subsequent anasarca and repeated penicillin treatments, generalized cutis laxa developed in a forty-year-old patient. Progressive signs of pulmonary emphysema appeared in the same period. Additionally, a monoclonal gammopathy was detected during extensive

Acquired cutis laxa concomitant with nephrotic syndrome.

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A 41-year-old woman developed laxity and wrinkling of the skin. This process spread slowly to involve the skin of almost the entire body, without any previous inflammatory skin disorder. The skin of her face, neck, and trunk hung in loose folds, leading to a prematurely aged appearance. One year

Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease.

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Transaldolase (TALDO) deficiency is a newly recognized metabolic disease, which has been reported so far in 2 patients presenting with liver failure and cirrhosis. We report a new sibship of 4 infants born to the same consanguineous parents; all presented at birth or in the antenatal period with

Fatal, penicillin-induced, generalized, postinflammatory elastolysis (cutis laxa).

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A 13-year-old boy received penicillin for influenza and otitis media. Within days of taking this medication, he developed recurrent edema of the face and a generalized urticarial eruption which waxed and waned. The salient and unusual features of this person's disease were: 1) A senile appearance of

Histologic assessment of dermatochalasis: elastolysis and lymphostasis are fundamental and interrelated findings.

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OBJECTIVE To determine the presence, degree, and extent of lymphatic, elastic, and collagen fiber alterations in dermatochalasis (DC) specimens. METHODS Case control study of patients with DC compared with age-, gender-, and site-matched controls. METHODS A total of 25 eyelid specimens were studied;

Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension.

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Our previous studies showed that increased pulmonary artery elastolytic activity is associated with monocrotaline-induced pulmonary hypertension in rats, and the latter is reduced by the elastase inhibitor SC-39026. This agent, given orally, decreases monocrotaline-induced muscularization of

Study of fibrous plaques occurring in the coronary arteries of children.

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The pathology of the coronary arteries of children, in relation to atherosclerotic involvement, appeared as a pathology of the main emergence areas and branching points of the left coronary artery and particularly of the anterior descending artery. The first atherosclerotic lesions occurred as

Light microscopic observations on fibrous plaque histogenesis in the coronary arteries of children.

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An attempt was made to reconstruct the succession of structural changes which lead to the onset of fibrous plaques in the coronary arteries of children. The results show that certain branch pads or cushions act as precursors of the first fibrous plaques. The conversion of branch pads into

The association of viral hepatitis and acute pancreatitis.

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The histological features of 24 pancreases obtained from patients who died of causes other than hepatitis, pancreatitis or pancreatic tumors, included a variable degree of autolysis, rare foci of inflammatory reaction but no hemorrhagic fat necrosis or destruction of elastic tissue in vessel walls

[Tuberculous papillitis].

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METHODS We describe a 65-year-old asymptomatic woman with unilateral optic disc edema. Laboratory testing revealed a very marked positive PPD (25 mm) with dermatolysis. Anti-tuberculosis therapy resulted in complete resolution. CONCLUSIONS Tuberculosis should be considered in the diagnosis of

[Collagenolysis above eccrine spiradenoma].

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BACKGROUND The casual observation of a peritumoral edema with collagenolysis in a case of eccrine spiradenoma led us to search for similar lesions in a retrospective series of 50 spiradenomas. METHODS Among 50 cases of eccrine spiradenomas, 36 excised with the overlying epidermis and the surrounding

Treatment of festoons by direct excision.

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BACKGROUND Festoons are redundant folds of loose skin, muscle, fat, and interstitial edema which extend from beyond the lateral cheek often past the midpupillary line, or even from canthus to canthus. Despite the fact that various treatments have been suggested for festoons, this entity still

Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.

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Transaldolase deficiency is a heterogeneous disorder of carbohydrate metabolism characterized clinically by dysmorphic features, cutis laxa, hepatosplenomegaly, hepatic fibrosis, pancytopenia, renal and cardiac abnormalities, and urinary excretion of polyols. This report describes four Emirati

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