A method for treatment of multiple sclerosis and related disease states. A histamine H2 mimicking agent is administered in an amount which is effective to stimulate production of a cyclic AMP in the body. A phosphodiesterase inhibitor is administered in conjunction with the histamine H2 mimicking agent to conserve the cyclic AMP which is thus produced. It is believed that the increased cyclic AMP levels serve to maintain the patient's myelin against self degeneration. The histamine H2 mimicking agent may be histamine phosphate and the phosphodiesterase inhibitor may be caffeine. The histamine H2 mimicking agent and the phosphodiesterase inhibitor may be mixed in a gel and administered using a transdermal patch.

Method for treatment of multiple sclerosis and related disease states

A method for treatment of neurodegenerative disease conditions stemming from multiple sclerosis, aging, autoimmune diseases and fibromyalgia. A compound effective to increase neuronal metabolism of histamine to a histamine H.sub.2 agonist is administered in an amount sufficient to stimulate production of cyclic AMP at a level which is sufficient to maintain myelin against undergoing self-degeneration. The compound is selected from the group consisting of histamine M-methyltransferase, monoamineoxidase-A, monoamineoxidase-A agonists and histamine H.sub.3 antagonists. The histamine M-methyltransferase may be administered to increase neuronal metabolism of histamine to tele-methylhistamine, whereas the monoamineoxidase-A or monoamineoxidase-A agonist may be administered so as to increase neuronal metabolism of telemethylhistamine to an H.sub.2 agonist. Separately or in conjunction with the others, the histamine H.sub.3 antagonist may be administered so as to inhibit metabolism of the telemethylhistamine to an H.sub.3 agonist, thereby increasing metabolism of the telemethylhistamine to an H.sub.2 agonist. The increased histamine H.sub.2 agonist levels reduce demyelination and the symptoms that are associated with these conditions.

cyclic amp/atrophy

Method for treatment of multiple sclerosis and related disease states

Method for treatment of neurodegenerative diseases and effects of aging

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