FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
This invention relates to novel aryl oxime-carbamates and carbonates having bronchodilatory and anti-inflammatory activities and being useful in the treatment of asthma.
Asthma is a disease in which respiratory distress is produced as a result of airway narrowing. This narrowing is caused largely by
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel compounds that are useful for
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel tetrazole compounds that are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel indazole compounds that are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel oxime and hydrazone compounds
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel tetrazole compounds that are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel compounds that are useful for
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3', 5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel oxime and hydrazone compounds
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel pyrazole compounds which are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP specific PDE). In particular, the present invention relates to a series of novel pyrazole compounds which are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP-specific PDE). In particular, the present invention relates to a series of novel pyrrole compounds that are
FIELD OF INVENTION
The present invention relates to a series of compounds that are potent and selective inhibitors of cyclic adenosine 3',5'-monophosphate specific phosphodiesterase (cAMP-specific PDE). In particular, the present invention relates to a series of novel pyrrole compounds that are
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