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Cyclopia: an anatomic and histologic study of two specimens.

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The craniofacial complex of two neonatal, human, cyclopic specimens was studied in detail. Both specimens exhibited a single ocular opening and one had a prominent probosics positioned in the midline directly superior to the ocular aperture. No external nasal development was noted in the other

Cyclopia: isolated and with agnathia-otocephaly complex.

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Cyclopia is a rare form of lethal holoprosencephaly (HPE) due to incomplete cleavage of prosencephalon during embryogenesis, leading to failure of the orbits of the eye to divide into two cavities. We report two cases, one with cyclopia and another case of cyclopia with agnathia-otocephaly complex

Ultrasonic findings in fetal cyclopia. A case report.

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The sonographic picture of fetal cyclopia at 33 weeks' gestation consists of a small fetal head, a central cavity replacing the cerebral lateral ventricles, lack of midline structures, absence of hemispheral vascular pattern and hydramnios. In addition, in our case a structure projecting from the

Floor of the median orbit in human cyclopia: an anatomical study in three dimensions.

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A three dimensional study has been undertaken of the floor of the median orbit in human cyclopia. The cyclopic material consists of a full term desiccated head, a dried fetal skull and four sectioned fetal heads. Most elements in the floor of the median orbit are normal. Such abnormalities as are

Congenital disorder of true cyclopia with polydactylia: case report and review of the literature.

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Cyclopia is a rare type of holoprosencephaly and a congenital disorder characterized by the failure of the embryonic forebrain to properly divide the orbits of the eye into two cavities (the embryonic forebrain is normally responsible for inducing the development of the orbits). As a result a birth

Cyclopia in one of discordant twins: a case report.

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Cyclopia is an uncommon congenital anomaly resulting from arrest of the development of the anterior end of the neural plate. It is always associated with abnormalities of the brain. Cyclopia has never been reported in one twin only. In this report, we describe a case of cyclopia in a female infant

3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia.

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BACKGROUND The purpose of this study was to examine a human fetus with combined holoprosencephaly and cyclopia by means of histology and 3-D reconstruction to determine the internal structure and extent of the malformation. METHODS The head from a human fetus at 20 weeks gestation and a diagnosis of

Cyclopia and proboscis - the extreme end of holoprosencephaly.

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Holoprosencephaly (HPE), a major congenital abnormality in brain development is characterized by the absence or incomplete cleavage of prosencephalon into separate hemispheres, with cyclopia as the extreme manifestation of HPE, presenting as a failure of embryonic prosencephalon to properly divide

Upper jaw in human cyclopia.

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In human cyclopia the upper jaw forms a solid bony mass between the median orbit and the oral cavity. The skeletal elements forming the upper jaw have been studied in serial sections through the median third of the head in 3 perinatal human specimens presenting with a median orbit and proboscis. One

The proboscis in human cyclopia: an anatomical study in two dimensions.

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A 2-dimensional anatomical study has been undertaken of the proboscis and its contribution to the roof of the median orbit in human cyclopia. The cyclops material consists of 4 sectioned fetal heads and a dried cyclops skull. The skeleton of the proboscis is formed by the nasal capsule. The base of

Palatine bone in human cyclopia.

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In human cyclopia, a maxillopalatine mass separates the median orbit from the oral cavity. The palatine component of this bony mass has been studied in serial sections through the median third of the head in three perinatal human specimens presenting with a median orbit and proboscis. One head was

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