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cynoglossum/fibrosis

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Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses.

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Houndstongue (Cynoglossum officinale), a noxious weed that contains pyrrolizidine alkaloids (PAs), infests pastures and fields in the western United States and Europe. The purpose of this study was to develop techniques to better diagnose PA poisoning and describe the progression of gross and

Cynoglossum officinale (hound's-tongue)--a cause of pyrrolizidine alkaloid poisoning in horses.

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The death of 10 horses was attributed to feeding dried grass hay containing hound's-tongue, Cynoglossum officinale. Affected horses developed weight loss, icterus, photosensitization, and hepatic encephalopathy. Histologic examination of the liver of 3 of the horses revealed megalocytosis, biliary
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