delta 9 tetrahydrocannabinol/cannabis

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Cannabis Impairment Detection Application (CIDA)

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At the University of Iowa, subjects who currently use cannabis recreationally (> once a month but < 5 times a week) will be recruited. They will then undergo a screening visit in which consent is obtained, questionnaires are given, and a physical exam is administered. They will then be scheduled for

Cannabis Oil for Pain in Parkinson's Disease

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BACKGROUND AND RATIONALE Pain is a common symptom in PD and is reported in up to 50 % of patients. Pain in PD has been classified as musculoskeletal, dystonic (particularly in OFF-periods), radicular and central pain, and is frequently associated with muscle rigidity, postural abnormalities and

Neural Correlates of Driving and Cannabis

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Safety and Efficacy of Cannabis in Tourette Syndrome

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Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

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Our objective is to assess 120 community-dwelling people living with HIV who have neuropathic pain and are currently using cannabis. These participants will be enrolled in a study that consists of two phases: Phase 1) This will involve a cross over study involving three different doses of vaporized

Study of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD

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Posttraumatic Stress Disorder (PTSD), characterized by an inability to recover from a stress reaction to a traumatic event, is a widely prevalent disorder within the U.S. and across the world. Currently, several psychotherapies are empirically-supported for the treatment of PTSD. However, because of

Duration of Marijuana Concentration in Breast Milk- A Pilot Study

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This prospective, observational pilot study will identify women within 72 hours of delivery who have a positive urine drug screen for THC and who intend to breastfeed. Eligibility will not be dependent upon the disposition of the infant, either discharged shortly after birth or infants with NICU

Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study

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Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids

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Trial of Dronabinol and Vaporized Cannabis in Neuropathic Low Back Pain

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The present study is designed to assess whether treatment with vaporized cannabis or dronabinol (oral Δ9-THC) reduces spontaneous and evoked pain more than placebo, and whether there are any differences between the two active treatments in terms of interference with activities of daily living. This

Pregnenolone and Marijuana Dependence

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Overview Thirty participants between the ages of 18 and 65 who meet DSM-V criteria for current for cannabis use disorder will complete a study visit. Participants will be randomized to receive either PREG (400 mg) (n=15) or placebo (PBO) (n=15). Two-hours after medication administration, the

Cannabinoids, Learning, and Memory

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This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.

Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics

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Objectives Cannabinoids are most commonly administered via smoking. Oral consumption in medications, teas, oils, or food also is widely utilized. Additionally, cannabis vaporization followed by inhalation for medical and illicit administration is common. Differences in cannabis pharmacodynamics and

Probing the Cannabinoid System in Individuals With a Family History of Psychosis

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Study of the Relationship Between Dose-concentration-effect of Delta-9-tetrahydrocannabinol (THC) and the Ability to Drive in Chronic or Occasional Cannabis Users

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This study will examine: - The relationship between THC blood levels and driving performance measured on a York Driving simulator - The relationship between THC blood levels and reaction times as measured on the psychomotor vigilance test (PVT) - the pharmacokinetics of THC in occasional and chronic

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