desmosterol/dyskinesias

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Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters.

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The dopamine transporter (DAT) is abundantly expressed in the striatum where it removes extracellular dopamine into the cytosol of presynaptic nerve terminals. It is the target of drugs of abuse and antidepressants. There is a loss of the DAT in Parkinson's disease affecting release of levodopa

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