diabetes mellitus type 1/phosphatase

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Use of islet glucose-6-phosphatase related protein as a diagnostic tool and therapeutic target for autoimmune diabetes

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REFERENCE TO SEQUENCE LISTING This application contains a Sequence Listing submitted as an electronic text file named "2848.sub.--56_PUS_DIV_ST25.txt" having a size in bytes of 19 KB, and created on Feb. 18, 2010. The information contained in this electronic file is hereby incorporated by reference

Inhibitors of protein tyrosine phosphatase

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FIELD OF THE INVENTION The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM). BACKGROUND OF THE INVENTION The mechanism of

Inhibitors of protein tyrosine phosphatase

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The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM). BACKGROUND OF THE INVENTION The mechanism of insulin action depends

Modulators of protein tyrosine phosphatases (PTPases)

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FIELD OF THE INVENTION The present invention relates to novel thienopyridines, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors

Protein tyrosine phosphatase inhibitors and methods of use thereof

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FIELD OF THE INVENTION This invention relates to the field of protein tyrosine phosphatase inhibition. BACKGROUND OF THE INVENTION This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B. Reversible protein tyrosine phosphorylation, coordinated by the

Protein tyrosine phosphatase inhibitors and methods of use thereof

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Antigens targeted by prevalent pathogennic T cells in type 1 diabetes and uses thereof

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BACKGROUND (1) Field of the Invention The present invention generally relates to diagnosis and therapy of type 1 diabetes. More specifically, the invention provides methods of diagnosis, prevention and therapy of type 1 diabetes based on the identification of the islet (3 cell antigen targeted by

Islet cell antigen 1851

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BACKGROUND OF THE INVENTION Detection of specific autoantigens in prediabetic individuals has been used as a predictive marker to identify, before clinical onset and significant .beta.-cell loss has occurred, those at greater risk of developing IDDM (Gorsuch et al., Lancet 2: 1363-65, 1981;

Islet cell antigen 1851

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BACKGROUND OF THE INVENTION Insulin-dependent diabetes mellitus (IDDM) is a disease resulting from the autoimmune destruction of the insulin-producing .beta.-cells of the pancreas. Studies directed at identifying the autoantigen(s) responsible for .beta.-cell destruction have generated several

C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is a .sctn.371 national stage of PCT International Application No. PCT/IB2013/051916, filed Mar. 11, 2013, claiming priority of Portuguese Patent Application No. 106202, filed Mar. 9, 2012, the contents of each of which are hereby incorporated

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