diabetic neuropathies/nausea

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Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study.

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To evaluate the efficacy and safety of 6 weeks of venlafaxine extended-release (ER) (75 mg and 150-225 mg) treatment in patients with painful diabetic neuropathy. This multicenter, double-blind, randomized, placebo-controlled study included 244 adult outpatients with metabolically stable type 1 or 2

The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy.

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The effect of the selective serotonin reuptake inhibitor citalopram on diabetic neuropathy symptoms was examined in a double-blind, placebo-controlled, crossover study for two 3-week periods. Citalopram was given as a fixed dose of 40 mg/day. Data from 15 patients could be included in the

Duloxetine in the treatment of chronic pain due to fibromyalgia and diabetic neuropathy.

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Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these

Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy.

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OBJECTIVE In patients with symptomatic diabetic polyneuropathy, is oral alpha-lipoic acid (ALA) effective in improving neuropathic symptoms compared with placebo? METHODS The question was addressed with a structured evidence-based clinical neurologic practice review via videoconferencing between 3

Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy.

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OBJECTIVE The objective of this study was to evaluate the efficacy and safety of tramadol in a 6-month open extension following a 6-week double-blind randomized trial. METHODS Patients with painful diabetic neuropathy who completed the double-blind study were eligible for enrollment in an open

Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy.

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OBJECTIVE The objective of this study was to evaluate the efficacy and safety of tramadol in treating the pain of diabetic neuropathy. BACKGROUND The pain of diabetic neuropathy is a major cause of morbidity among these patients and treatment, as with other small-fiber neuropathies, is often

Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials.

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BACKGROUND Duloxetine hydrochloride is a reuptake inhibitor of 5-hydroxytryptamine and norepinephrine used to treat depression, generalized anxiety disorder, neuropathic pain, and stress incontinence in women. We investigated the efficacy of duloxetine in painful diabetic neuropathy and fibromyalgia

Mexiletine. A review of its therapeutic use in painful diabetic neuropathy.

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Mexiletine is an orally active local anaesthetic agent which is structurally related to lidocaine (lignocaine) and has been used for alleviating neuropathic pain of various origins. Mexiletine has been evaluated in several randomised, placebo-controlled trials in patients with painful diabetic

Diabetic neuropathy in the gut: pathogenesis and diagnosis.

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The activity of the digestive tract is usually regulated to match its content: physiological stimuli in the gut induce modulatory reflexes that control digestive function so that digestion is normally not perceived. However, under certain circumstances, digestive stimuli may activate sensory

Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting.

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BACKGROUND Factors associated with abdominal pain in gastroparesis are incompletely evaluated and comparisons of pain vs other symptoms are limited. This study related pain to clinical factors in gastroparesis and contrasted pain/discomfort- with nausea/vomiting-predominant disease. METHODS Clinical

Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy.

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Diabetic neuropathy is one of the most common long-term complications in patients with diabetes mellitus, with a prevalence of 60-70% in the United States. Treatment options include antidepressants, anticonvulsants, tramadol, and capsaicin. These agents are modestly effective for symptomatic relief,

Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebo-controlled trial.

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The efficacy and tolerability of oral lacosamide (200, 400, and 600 mg/day) was evaluated in patients with painful diabetic neuropathy in a double-blind, randomized, placebo-controlled trial. The primary target dose to be confirmed was lacosamide 400 mg/day. Efficacy was assessed by changes in pain

Gangrenous cholecystitis: A silent but potential fatal disease in patients with diabetic neuropathy. A case report.

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Gangrenous cholecystitis (GC) is a severe and potentially deadly complication of acute cholecystitis. We present a 83-year-old gentleman with a past medical history of type 2 diabetes mellitus with significant associated neuropathy, presenting to a community hospital in a major metropolitan area

Diabetic autonomic neuropathy causing gall bladder dysfunction.

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OBJECTIVE The objective of the study was to study gall bladder volume in fasting and 45 minutes post-prandial, by real time ultrasound in healthy controls and diabetic patients with and without autonomic neuropathy and to compare them. METHODS Age, Sex and body mass index (BMI) matched 50 healthy

Evaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover study.

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Nineteen diabetic patients with autonomic neuropathy were enrolled in a double-blind crossover study of cisapride, metoclopramide and placebo. Symptoms were evaluated from diary cards and from assessments undertaken at the end of each eight week treatment period. Measurements of oesophageal transit,

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