diabetic neuropathies/nicotine

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Prevalence of diabetic neuropathy in patients undergoing foot and ankle surgery.

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BACKGROUND The aim of this prospective study was to determine the prevalence of neuropathy in diabetic patients undergoing foot and ankle surgery. It was hypothesized that the prevalence of diabetic neuropathy is higher among patients who undergo foot and ankle surgery compared with historical rates

[Diabetic neuropathy: therapeutic nihilism is no longer acceptable].

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The repeatedly expressed doubts about the value of an effective therapy for diabetic neuropathies are no longer acceptable. Today a number of excellent longitudinal and cross-sectional studies, i.e. DCCT, Steno 2, DCCT/EDIC, European Diabetes Prospective Complications Study, are available. The

Smoking habits and painful diabetic neuropathy.

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In order to assess the relationship between chronic painful diabetic neuropathy and current--or lifetime--smoking habits, the smoking history of 49 diabetic patients was investigated and compared with that of 23 diabetic patients without chronic pain (age 51.0 +/- 1.9 years, mean +/- SEM). Current

A cross-sectional study to estimate the point prevalence of painful diabetic neuropathy in Eastern Libya.

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Painful Diabetic Neuropathy (PDN) is a complication that affects up to one third of people living with diabetes. There is limited data on the prevalence of PDN from countries in the Middle East and North Africa. The aim of this study was to estimate the point prevalence of PDN in

[Erectile dysfunction. An important manifestation of autonomic diabetic neuropathy].

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In Germany, some 4-6 million men, including 1.2 million diabetics, suffer from erectile dysfunction (ED). Various other diseases including heart disease, hypertension, arteriosclerosis, hyperlipidemia, endocrine disorders, chronic renal insufficiency, prior radical prostatectomy, neurological

Novel actions of progesterone: what we know today and what will be the scenario in the future?

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OBJECTIVE This article is aimed to review the novel actions of progesterone, which otherwise is considered as a female reproductive hormone. The article focuses on its important physiological actions in males too and gives an overview of its novel perspectives in disorders of central and peripheral

[Serum alpha-1 antitrypsin levels in patients with Cuban epidemic neuropathy].

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BACKGROUND Cuban epidemic neuropathy is an emergent disease that due to its magnitude and health problem it was considered the most devastating outbreak of the XX century of the world. On the other hand it has been reported that the protease inhibitor, in particular alpha 1 antitrypsin has

A preclinical training model for chronic care education.

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BACKGROUND Chronic illnesses are not only major health threats for half of the world's population, but these diseases are also increasing rapidly. Medical training, however, has not kept pace with this increase in chronic illness. METHODS I describe two instructional modules whose goals were to

Population analyses of efficacy and safety of ABT-594 in subjects with diabetic peripheral neuropathic pain.

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ABT-594, a neuronal nicotinic acetylcholine receptor ligand, is 30- to 100-fold more potent than morphine in animal models of nociceptive and neuropathic pain. Efficacy and safety of ABT-594 in subjects with painful diabetic polyneuropathy was evaluated in a phase 2 study. The objective of this work

Factors influencing sweat gland innervation in diabetes.

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BACKGROUND Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine

Population pharmacokinetics of ABT-594 in subjects with diabetic peripheral neuropathic pain.

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OBJECTIVE ABT-594 is a non-opioid, non-NSAID analgesic. The objective of this work was to characterize the population pharmacokinetics of ABT-594 in subjects with neuropathic pain. METHODS Efficacy, safety and pharmacokinetics of ABT-594 in subjects with painful diabetic polyneuropathy were

Medical complications associated with substance use disorders in patients with type 2 diabetes and hypertension: electronic health record findings.

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Screening for substance use disorder (SUD) in general medical settings may be particularly important in patients with comorbid health conditions exacerbated by SUD. This study evaluated whether SUD is associated with type 2 diabetes mellitus (T2DM) complications in patients with

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