diabetic neuropathies/obesity

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Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds

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FIELD OF INVENTION The present invention relates to a method of making novel dipeptidyl peptidase-IV ("DPP-IV`) inhibitor compounds and a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds. BACKGROUND OF

Benzene compounds

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to benzene compounds, and more particularly, to novel benzene compounds having inhibition activity on acetyl CoA carboxylase ("ACC" hereinafter). 2. Discussion of the Background It has become clear in recent years

Lactam compound, a method for producing the same, and a diabetic therapy by administering the same

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicinal drug, and in particular, to a novel lactam compound having sugar transport enhancement action and having excellent hypoglycemic action, a preparation method thereof, and a preparation intermediate

Combinations

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COMBINATIONS The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) a PDE 5 inhibitor or a pharmaceutically acceptable salt thereof and (b) at least one active ingredient selected from the group consisting of (i) an anti-diabetic agent; (ii) HMG-Co-A

Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors

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FIELD OF THE INVENTION The present invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV (hereinafter "DPP-IV"), pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with

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